Top

Published in:

01-03-2021 | Polyneuropathy | Brief Communication

Myelin oligodendrocyte glycoprotein-IgG-positive, steroid-responsive combined central and peripheral demyelination with recurrent peripheral neuropathy

Authors: Takaaki Nakamura, Kimihiko Kaneko, Genya Watanabe, Shogo Harashima, Emiko Kawasaki, Kenichi Tsukita, Toshiyuki Takahashi, Ichiro Nakashima, Tatsuro Misu, Yasushi Suzuki

Published in: Neurological Sciences | Issue 3/2021

Abstract

Myelin oligodendrocyte glycoprotein (MOG)-IgG detected by the cell-based assay is associated with demyelinating diseases of the central nervous system, such as optic neuritis, myelitis, and acute disseminated encephalomyelitis, but rarely with peripheral neuropathy. Here, we describe the case of a 32-year-old MOG-IgG⁺ woman who developed central and peripheral demyelinating lesions. In contrast to previous similar cases, she uniquely presented with repeated subsequent relapses in the peripheral nerve, mimicking chronic inflammatory demyelinating polyneuropathy. Possible pathogenic implications of MOG-IgG in combined central and peripheral nervous system diseases are considered.

Reindl M, Di Pauli F, Rostasy K, Berger T (2013) The spectrum of MOG autoantibody-associated demyelinating diseases. Nat Rev Neurol 9:455–461CrossRef

Vazquez Do Campo R, Stephens A, Marin Collazo IV, Rubin DI (2018) MOG antibodies in combined central and peripheral demyelination syndromes. Neurol Neuroimmunol Neuroinflamm 5:e503CrossRef

Sundaram S, Nair SS, Jaganmohan D, Unnikrishnan G, Nair M (2020) Relapsing lumbosacral myeloradiculitis: an unusual presentation of MOG antibody disease. Mult Scler 26:509–511CrossRef

Nakamura M, Fujimori J, Kobayashi M, Ishigaki A, Kikuchi H, Miyazawa K, Sato K, Kawasaki E, Suzuki Y, Nakashima I (2020) Refractory case of myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis with lumbosacral radiculitis. Clin Exp Neuroimmunol 11:126–130. https://doi.org/10.1111/cen3.12564CrossRef

Ogata H, Matsuse D, Yamasaki R, Kawamura N, Matsushita T, Yonekawa T, Hirotani M, Murai H, Kira J (2016) A nationwide survey of combined central and peripheral demyelination in Japan. J Neurol Neurosurg Psychiatry 87:29–36PubMed

Kaneko K, Sato DK, Nakashima I, Ogawa R, Akaishi T, Takai Y, Nishiyama S, Takahashi T, Misu T, Kuroda H, Tanaka S, Nomura K, Hashimoto Y, Callegaro D, Steinman L, Fujihara K, Aoki M (2018) CSF cytokine profile in MOG-IgG+ neurological disease is similar to AQP4-IgG+ NMOSD but distinct from MS: a cross-sectional study and potential therapeutic implications. J Neurol Neurosurg Psychiatry 89:927–936CrossRef

Ogata H, Yamasaki R, Hiwatashi A, Oka N, Kawamura N, Matsuse D, Kuwahara M, Suzuki H, Kusunoki S, Fujiomto Y, Ikezoe K, Kishida H, Tanaka F, Matsushita T, Murai H, Kira J (2015) Characterization of IgG4 anti-neurofascin 155 antibody-positive polyneuropathy. Ann Clin Transl Neurol 2:960–971CrossRef

Cobo-Calvo A, Ruiz A, Maillart E, Audoin B, Zephir H, Bourre B, Ciron J, Collongues N, Brassat D, Cotton F, Papeix C, Durand-Dubief F, Laplaud D, Deschamps R, Cohen M, Biotti D, Ayrignac X, Tilikete C, Thouvenot E, Brochet B, Dulau C, Moreau T, Tourbah A, Lebranchu P, Michel L, Lebrun-Frenay C, Montcuquet A, Mathey G, Debouverie M, Pelletier J, Labauge P, Derache N, Coustans M, Rollot F, de Seze J, Vukusic S, Marignier R, OFSEP and NOMADMUS Study Group (2018) Clinical spectrum and prognostic value of CNS MOG autoimmunity in adults: the MOGADOR study. Neurology 90:e1858–e1869CrossRef

Oliveira LM, Apóstolos-Pereira SL, Pitombeira MS, Bruel Torretta PH, Callegaro D, Sato DK (2019) Persistent MOG-IgG positivity is a predictor of recurrence in MOG-IgG-associated optic neuritis, encephalitis and myelitis. Mult Scler 25:1907–1914CrossRef

10.

Pagany M, Jagodic M, Schubart A, Pham-Dinh D, Bachelin C, Baron van Evercooren A, Lachapelle F, Olsson T, Linington C (2003) Myelin oligodendrocyte glycoprotein is expressed in the peripheral nervous system of rodents and primates. Neurosci Lett 350:165–168CrossRef

Title: Myelin oligodendrocyte glycoprotein-IgG-positive, steroid-responsive combined central and peripheral demyelination with recurrent peripheral neuropathy
Authors: Takaaki Nakamura
Kimihiko Kaneko
Genya Watanabe
Shogo Harashima
Emiko Kawasaki
Kenichi Tsukita
Toshiyuki Takahashi
Ichiro Nakashima
Tatsuro Misu
Yasushi Suzuki
Publication date: 01-03-2021
Publisher: Springer International Publishing
Keywords: Polyneuropathy
Optic Neuritis
Demyelinating Disease
Published in: Neurological Sciences / Issue 3/2021
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-04822-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Myelin oligodendrocyte glycoprotein-IgG-positive, steroid-responsive combined central and peripheral demyelination with recurrent peripheral neuropathy

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2021

Proposed minimal essential co-expression and physical interaction networks involved in the development of cognition impairment in human mid and late life

A case of diffuse large B cell lymphoma initially presenting as CLIPPERS: possible role of the Epstein–Barr virus

Infectious disease in asylums: a fact-finding investigation to prevent tuberculosis contagion in the early twentieth century in Italy

Pitfalls in the diagnosis of herpes simplex virus-1 encephalitis: case report

Reassessing IVIg therapy in chronic inflammatory demyelinating polyradiculoneuropathy during COVID-19: a chance to verify the need for chronic maintenance therapy

COVID-19 impact on neurology training program in Italy