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Open Access 01-12-2023 | Review

Quantitative perfusion assessment using indocyanine green during surgery — current applications and recommendations for future use

Authors: P. Van Den Hoven, J. Osterkamp, N. Nerup, M. B. S. Svendsen, Alexander Vahrmeijer, J. R. Van Der Vorst, M. P. Achiam

Published in: Langenbeck's Archives of Surgery | Issue 1/2023

Abstract

Purpose

Incorrect assessment of tissue perfusion carries a significant risk of complications in surgery. The use of near-infrared (NIR) fluorescence imaging with Indocyanine Green (ICG) presents a possible solution. However, only through quantification of the fluorescence signal can an objective and reproducible evaluation of tissue perfusion be obtained. This narrative review aims to provide an overview of the available quantification methods for perfusion assessment using ICG NIR fluorescence imaging and to present an overview of current clinically utilized software implementations.

Methods

PubMed was searched for clinical studies on the quantification of ICG NIR fluorescence imaging to assess tissue perfusion. Data on the utilized camera systems and performed methods of quantification were collected.

Results

Eleven software programs for quantifying tissue perfusion using ICG NIR fluorescence imaging were identified. Five of the 11 programs have been described in three or more clinical studies, including Flow® 800, ROIs Software, IC Calc, SPY-Q™, and the Quest Research Framework®. In addition, applying normalization to fluorescence intensity analysis was described for two software programs.

Conclusion

Several systems or software solutions provide a quantification of ICG fluorescence; however, intraoperative applications are scarce and quantification methods vary abundantly. In the widespread search for reliable quantification of perfusion with ICG NIR fluorescence imaging, standardization of quantification methods and data acquisition is essential.

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Title: Quantitative perfusion assessment using indocyanine green during surgery — current applications and recommendations for future use
Authors: P. Van Den Hoven
J. Osterkamp
N. Nerup
M. B. S. Svendsen
Alexander Vahrmeijer
J. R. Van Der Vorst
M. P. Achiam
Publication date: 01-12-2023
Publisher: Springer Berlin Heidelberg
Published in: Langenbeck's Archives of Surgery / Issue 1/2023
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-023-02780-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Quantitative perfusion assessment using indocyanine green during surgery — current applications and recommendations for future use

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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