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European Archives of Oto-Rhino-Laryngology

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01-11-2021 | Salivary Gland Cancer | Head and Neck

Patterns of care, toxicity and outcome in the treatment of salivary gland carcinomas: long-term experience from a tertiary cancer center

Authors: Jens von der Grün, Ria Winkelmann, Franz Rödel, Sven Balster, Thomas Neumayer, Shahram Ghanaati, Christian Brandts, Iris Burck, Daniel Martin, Claus Rödel, Nikolina Kesar, Panagiotis Balermpas

Published in: European Archives of Oto-Rhino-Laryngology | Issue 11/2021

Abstract

Background

Salivary gland carcinomas (SGC) cover a heterogeneous group of malignancies with a lack of data of high-level evidence.

Methods

Clinical data of 127 patients treated for SGC at a university cancer center between 2002 and 2017 were analyzed retrospectively. The association of clinicopathological characteristics, treatment modalities, adverse events, and outcome was assessed.

Results

Patients received surgery (n = 65), surgery followed by (chemo-)radiotherapy (n = 56), or primary (chemo-)radiotherapy (n = 6). Injury to the cranial nerves or their branches was the most frequent surgical complication affecting 40 patients (33.1%). Ten year overall and progression-free survival rates were 73.2% and 65.4%, respectively. Parotid tumor site, advanced tumor, and positive nodal stage remained independent negative prognostic factors for overall survival, loco-regional and distant tumor control in multivariate analysis.

Conclusions

Optimizing treatment strategies for SGC, depending on distinct clinicopathological factors, remains challenging due to the low incidence rates of the disease.

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Title: Patterns of care, toxicity and outcome in the treatment of salivary gland carcinomas: long-term experience from a tertiary cancer center
Authors: Jens von der Grün
Ria Winkelmann
Franz Rödel
Sven Balster
Thomas Neumayer
Shahram Ghanaati
Christian Brandts
Iris Burck
Daniel Martin
Claus Rödel
Nikolina Kesar
Panagiotis Balermpas
Publication date: 01-11-2021
Publisher: Springer Berlin Heidelberg
Keywords: Salivary Gland Cancer
Parotidectomy
Neck Dissection
Care
Radiotherapy
Salivary Gland Cancer
Published in: European Archives of Oto-Rhino-Laryngology / Issue 11/2021
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-021-06652-5

2024 ASCO Annual Meeting

Springer Medicine

Patterns of care, toxicity and outcome in the treatment of salivary gland carcinomas: long-term experience from a tertiary cancer center

Abstract

Background

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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