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Open Access 01-12-2011 | Review

An overview of the rare parotid gland cancer

Authors: Kimberley Ho, Helen Lin, David K Ann, Peiguo G Chu, Yun Yen

Published in: Head & Neck Oncology | Issue 1/2011

Abstract

Cancer of the parotid gland is relatively rare, but carries poor prognosis owing to its prevailing distant metastases. In addition to the disease's basic epidemiology and pathology, we review some current discoveries of its tumorigenesis molecular mechanism. Based on published salivary gland cancer clinical trial data, non-surgical antitumor efficacies amongst a range of chemotherapy, radiation, and concurrent therapy regimens are compared. We also present the current development status of novel radiation therapy and targeted therapeutics, focusing on intensity-modulated radiation therapy (IMRT), and epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) blockages, which are showing promise for improving parotid gland cancer management.

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Title: An overview of the rare parotid gland cancer
Authors: Kimberley Ho
Helen Lin
David K Ann
Peiguo G Chu
Yun Yen
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Head & Neck Oncology / Issue 1/2011
Electronic ISSN: 1758-3284
DOI: https://doi.org/10.1186/1758-3284-3-40

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