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European Journal of Nuclear Medicine and Molecular Imaging

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01-03-2021 | Positron Emission Tomography | Original Article

Clinical feasibility and impact of fully automated multiparametric PET imaging using direct Patlak reconstruction: evaluation of 103 dynamic whole-body ¹⁸F-FDG PET/CT scans

Authors: André H. Dias, Mette F. Pedersen, Helle Danielsen, Ole L. Munk, Lars C. Gormsen

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2021

Abstract

Purpose

Functional imaging by standard whole-body (WB) ¹⁸F-flurodeoxyglucose (FDG) positron emission tomography (PET) is an integrated part of disease diagnostics. Recently, a clinical dynamic whole-body (D-WB) FDG PET/CT scanning protocols has been developed allowing for quantitative imaging of tissue metabolic rate of FDG (MR_FDG). It was the purpose of this retrospective study to evaluate whether MR_FDG imaging is feasible in a clinical setting and whether it improves lesion detectability.

Methods

One hundred nine patients representing a broad range of referral indications for FDG PET/CT were invited to undergo a D-WB FDG PET/CT scan. Two sets of images were produced: parametric images and standard static SUV images. Both sets of images were reviewed visually, and 310 individual lesions were quantitatively analysed using the target-to-background (TBR) and contrast-to-noise (CNR) metrics.

Results

One hundred three out of 109 patients completed the D-WB FDG PET/CT scan. There was no difference in the number of pathological lesions identified visually on the MR_FDG and the SUV images, whereas MR_FDG images yielded 4 fewer false positives than the SUV images. Quantitatively, MR_FDG TBR was significantly higher than SUV TBR in 299/310 lesions, and better MR_FDG CNR was found to facilitate the challenging reading of lesions with low SUV TBR.

Conclusion

D-WB FDG PET/CT is feasible in a clinical setting and produces MR_FDG images of good visual quality and superior lesion contrast. In addition, MR_FDG images complement the standard SUV images providing better quantification and enhanced image reading. However, although MR_FDG also reduced the number of false-positive findings, no additional malignant lesions were identified. The technique therefore appears to be best suited for select patient groups or possibly treatment response evaluation.

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Title: Clinical feasibility and impact of fully automated multiparametric PET imaging using direct Patlak reconstruction: evaluation of 103 dynamic whole-body 18F-FDG PET/CT scans
Authors: André H. Dias
Mette F. Pedersen
Helle Danielsen
Ole L. Munk
Lars C. Gormsen
Publication date: 01-03-2021
Publisher: Springer Berlin Heidelberg
Keyword: Positron Emission Tomography
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2021
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-020-05007-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical feasibility and impact of fully automated multiparametric PET imaging using direct Patlak reconstruction: evaluation of 103 dynamic whole-body ¹⁸F-FDG PET/CT scans

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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