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01-04-2020 | Mastectomy | Original Article

Long-term quality of life after preoperative radiochemotherapy in patients with localized and locally advanced breast cancer

Authors: Jan Haussmann, Carolin Nestle-Kraemling, Edwin Bölke, Sylvia Wollandt, Vanessa Speer, Freddy-Joel Djiepmo Njanang, Bálint Tamaskovics, Peter Arne Gerber, Klaus Orth, Eugen Ruckhaeberle, Tanja Fehm, Stefanie Corradini, Guido Lammering, Svjetlana Mohrmann, Werner Audretsch, Kitti Maas, Stephan Roth, Kai Kammers, Wilfried Budach, Christiane Matuschek

Published in: Strahlentherapie und Onkologie | Issue 4/2020

Abstract

Background

Preoperative radiotherapy (PRT) or radiochemotherapy (PRCT) is used in different tumor sites. The aim of the study was to examine the long-term quality of life (QoL) of localized / locally advanced breast cancer patients treated with PRT/PRCT followed by breast-conserving surgery (BCS) or mastectomy (ME).

Methods

Assessment of QoL was done using EORTC QLQ-C30 questionnaires for overall QoL and EORTC QLQ-BR23 for breast-specific QoL. The summary scores were categorized into 4 distinct groups to classify the results. Furthermore, a comparative analysis was performed between the study cohort and a previously published reference cohort of healthy adults. We assessed the impact of different clinical, prognostic, and treatment-related factors on selected items from C30 and BR23 using a dependence analysis.

Results

Out of 315 patients treated with PRT/PCRT in the years 1991 to 1999, 203 patients were alive at long-term follow-up after a mean of 17.7 years (range 14–21). 37 patients were lost to follow-up and 61 patients refused to be contacted, leading to 105 patients (64 patients after BCS and 41 after ME) being willing to undergo further clinical assessment regarding QoL outcome. Overall, QoL (QLQ-C30) was rated “excellent” or “good” in 85% (mean value) of all patients (BCS 83%, ME 88%). Comparative analysis between the study cohort and a published healthy control group revealed significantly better global health status and physical and role functioning scores in the PRT/PRCT group. The analysis demonstrates no differences in nausea/vomiting, dyspnea, insomnia, constipation, or financial difficulties. According to the dependence analysis, global QoL was associated with age, operation type and ME reconstruction.

Conclusion

We did not detect any inferiority of PRT/PRCT compared to a healthy reference group with no hints of a detrimental long-term effect on general and breast-specific quality of life.

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Title: Long-term quality of life after preoperative radiochemotherapy in patients with localized and locally advanced breast cancer
Authors: Jan Haussmann
Carolin Nestle-Kraemling
Edwin Bölke
Sylvia Wollandt
Vanessa Speer
Freddy-Joel Djiepmo Njanang
Bálint Tamaskovics
Peter Arne Gerber
Klaus Orth
Eugen Ruckhaeberle
Tanja Fehm
Stefanie Corradini
Guido Lammering
Svjetlana Mohrmann
Werner Audretsch
Kitti Maas
Stephan Roth
Kai Kammers
Wilfried Budach
Christiane Matuschek
Publication date: 01-04-2020
Publisher: Springer Berlin Heidelberg
Keywords: Mastectomy
Breast Cancer
Breast Cancer
Radiotherapy
Published in: Strahlentherapie und Onkologie / Issue 4/2020
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-019-01557-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Long-term quality of life after preoperative radiochemotherapy in patients with localized and locally advanced breast cancer

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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