Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Clinical Neuroradiology
Published in: Clinical Neuroradiology 1/2019

01-03-2019 | Ependymoma | Clinical Case

Freiburg Neuropathology Case Conference

Posterior Fossa Mass in an Infant

Authors: C. A. Taschner, D. Erny, M. J. Shah, H. Urbach, U. Feige, M. Prinz

Published in: Clinical Neuroradiology | Issue 1/2019

Login to get access

Excerpt

A 10-month-old boy became conspicuous 4–6 weeks before hospital admission with backward tilting of his head. He was finally admitted to hospital for decreased vigilance that had started 2 days prior to admission. Apart from anisocoric pupils the patient did not show any neurological deficits on admission. Magnetic resonance imaging (MRI) of the head showed an obstructive hydrocephalus in relation with a massive posterior fossa tumor. An external ventricular drainage was immediately placed. The subsequent craniotomy and operative excision of the tumor was performed with the patient in prone position. The tumor appeared cystic, with moderate bleeding and showed necrotic components. The tumor was resected down to the level of the fourth ventricle. Ventral to this level a separation from the cranial nerves and the brain stem was not possible, so that a significant amount of residual tumor remained. The postoperative course was uneventful. Apart from a slight strabismus there were no new postoperative neurological deficits. Due to a persisting hydrocephalus, a ventriculoperitoneal shunt was implanted 2 weeks later. The patient was discharged home 3 days after the second procedure. …
Literature
1.
Spennato P, Nicosia G, Quaglietta L, Donofrio V, Mirone G, Di Martino G, Guadagno E, del Basso de Caro ML, Cascone D, Cinalli G. Posterior fossa tumors in infants and neonates. Childs Nerv Syst. 2015;31:175–7.CrossRef
2.
Lee YY, Van Tassel P, Bruner JM, Moser RP, Share JC. Juvenile pilocytic astrocytomas: CT and MR characteristics. AJR Am J Roentgenol. 1989;152:1263–70.CrossRefPubMed
3.
Nakano Y, Yamamoto J, Takahashi M, Soejima Y, Akiba D, Kitagawa T, Ueta K, Miyaoka R, Umemura T, Nishizawa S. Pilocytic astrocytoma presenting with atypical features on magnetic resonance imaging. J Neuroradiol. 2015;42:278–82.CrossRefPubMed
4.
Gaudino S, Martucci M, Russo R, Visconti E, Gangemi E, D’Argento F, Verdolotti T, Lauriola L, Colosimo C. MR imaging of brain pilocytic astrocytoma: Beyond the stereotype of benign astrocytoma. Childs Nerv Syst. 2017;33:35–54.CrossRefPubMed
5.
Rumboldt Z, Camacho DL, Lake D, Welsh CT, Castillo M. Apparent diffusion coefficients for differentiation of cerebellar tumors in children. AJNR Am J Neuroradiol. 2006;27(6):1362–9.PubMed
6.
Zitouni S, Koc G, Doganay S, Saracoglu S, Gumus KZ, Ciraci S, Coskun A, Unal E, Per H, Kurtsoy A, Kontas O. Apparent diffusion coefficient in differentiation of pediatric posterior fossa tumors. Jpn J Radiol. 2017;35:448–53.CrossRefPubMed
7.
Domínguez-Pinilla N, Martínez de Aragón A, Diéguez Tapias S, Toldos O, Hinojosa Bernal J, Rigal Andrés M, González-Granado LI. Evaluating the apparent diffusion coefficient in MRI studies as a means of determining paediatric brain tumour stages. Evaluación de la utilidad del coeficiente de difusión aparente en resonancia magnética para la diferenciación del grado tumoral de los tumores cerebrales pediátricos. Neurologia. 2016;31:459–65.CrossRefPubMed
8.
Alkonyi B, Nowak J, Gnekow A, Pietsch T, Warmuth-Metz M. Differential imaging characteristics and dissemination potential of pilomyxoid astrocytomas versus pilocytic astrocytomas. Neuroradiology. 2015;57:625–38.CrossRefPubMed
9.
Colafati GS, Voicu IP, Carducci C, Miele E, Carai A, Di Loreto S, Marrazzo A, Cacchione A, Cecinati V, Tornesello A, Mastronuzzi A. MRI features as a helpful tool to predict the molecular subgroups of medulloblastoma: State of the art. Ther Adv Neurol Disord. 2018;11:17–9.CrossRef
10.
Kline CN, Packer RJ, Hwang EI, Raleigh DR, Braunstein S, Raffel C, Bandopadhayay P1, Solomon DA1, Aboian M1, Cha S1, Mueller S1. Case-based review: Pediatric medulloblastoma. Neurooncol Pract. 2017;4:138–50.CrossRefPubMedPubMedCentral
11.
Rodriguez Gutierrez D, Awwad A, Meijer L, Manita M, Jaspan T, Dineen RA, Grundy RG, Auer DP. Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors. AJNR Am J Neuroradiol. 2014;35:1009–15.CrossRefPubMed
12.
Erdem E, Zimmerman RA, Haselgrove JC, Bilaniuk LT, Hunter JV. Diffusion-weighted imaging and fluid attenuated inversion recovery imaging in the evaluation of primitive neuroectodermal tumors. Neuroradiology. 2001;43:927–33.CrossRefPubMed
13.
Rollins N, Mendelsohn D, Mulne A, Barton R, Diehl J, Reyes N, Sklar F. Recurrent medulloblastoma: Frequency of tumor enhancement on Gd-DTPA MR imaging. AJNR Am J Neuroradiol. 1990;11:583–7.PubMed
14.
Bühring U, Strayle-Batra M, Freudenstein D, Scheel-Walter HG, Küker W. MRI features of primary, secondary and metastatic medulloblastoma. Eur Radiol. 2002;12:1342–8.CrossRefPubMed
15.
Aboian MS, Kline CN, Li Y, Solomon DA, Felton E, Banerjee A, Braunstein SE, Mueller S, Dillon WP, Cha S. Early detection of recurrent medulloblastoma: The critical role of diffusion-weighted imaging. Neurooncol Pract. 2018;5:234–40.PubMed
16.
Koral K, Gargan L, Bowers DC, Gimi B, Timmons CF, Weprin B, Rollins NK. Imaging characteristics of atypical teratoid-rhabdoid tumor in children compared with medulloblastoma. AJR Am J Roentgenol. 2008;190:809–14.CrossRefPubMed
17.
Tekautz TM, Fuller CE, Blaney S, Fouladi M, Broniscer A, Merchant TE, Krasin M, Dalton J, Hale G, Kun LE, Wallace D, Gilbertson RJ, Gajjar A. Atypical teratoid/rhabdoid tumors (ATRT): Improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy. J Clin Oncol. 2005;23:1491–9.CrossRefPubMed
18.
19.
20.
Zacharoulis S, Ji L, Pollack IF, Duffner P, Geyer R, Grill J, Schild S, Jaing TH, Massimino M, Finlay J, Sposto R. Metastatic ependymoma: A multi-institutional retrospective analysis of prognostic factors. Pediatr Blood Cancer. 2008;50:231–5.CrossRefPubMed
21.
McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M, Tihan T, Preston-Martin S. Trends in childhood brain tumor incidence, 1973–2009. J Neurooncol. 2013;115:153–60.CrossRefPubMedPubMedCentral
22.
Barkovich AJ. Pediatric neuroimaging. Philadelphia: Lippincott Williams & Wilkins; 2005.
23.
Swartz JD, Zimmerman RA, Bilaniuk LT. Computed tomography of intracranial ependymomas. Radiology. 1982;143:97–101.CrossRefPubMed
24.
25.
Otero JJ, Rowitch D, Vandenberg S. OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms. J Neurooncol. 2011;104:423–38.CrossRefPubMed
26.
Spence T, Sin-Chan P, Picard D, Barszczyk M, Hoss K, Lu M, Kim SK, Ra YS, Nakamura H, Fangusaro J, Hwang E, Kiehna E, Toledano H, Wang Y, Shi Q, Johnston D, Michaud J, La Spina M, Buccoliero AM, Adamek D, Camelo-Piragua S, Peter Collins V, Jones C, Kabbara N, Jurdi N, Varlet P, Perry A, Scharnhorst D, Fan X, Muraszko KM, Eberhart CG, Ng HK, Gururangan S, Van Meter T, Remke M, Lafay-Cousin L, Chan JA, Sirachainan N, Pomeroy SL, Clifford SC, Gajjar A, Shago M, Halliday W, Taylor MD, Grundy R, Lau CC, Phillips J, Bouffet E, Dirks PB, Hawkins CE, Huang A. CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity. Acta Neuropathol. 2014;128:291–303.CrossRefPubMedPubMedCentral
27.
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, editors. WHO classification of tumours of the central nervous system. Lyon: International Agency for Research on Cancer; 2016.
28.
Biegel JA, Zhou JY, Rorke LB, Stenstrom C, Wainwright LM, Fogelgren B. Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors. Cancer Res. 1999;59:74–9.PubMed
29.
Purdy E, Johnston DL, Bartels U, Fryer C, Carret AS, Crooks B, Eisenstat DD, Lafay-Cousin L, Larouche V, Wilson B, Zelcer S, Silva M, Bouffet E, Keene D, Strother DR. Ependymoma in children under the age of 3 years: A report from the Canadian Pediatric Brain Tumour Consortium. J Neurooncol. 2014;117:359–64.CrossRefPubMed
30.
Duncan J, Lows E Jr. Intracranial ependymomas. In: Kaye A, Lows E Jr, editors. Brain tumors. Edinburgh: Churchill Livingstone; 1995. pp. 493–504.
31.
Taschner CA, Erny D, Shah MJ, Urbach H, Lutz K, Prinz M. Freiburg Neuropathology Case Conference: An infant with a supratentorial mass lesion. Clin Neuroradiol. 2015;25:211–7.CrossRefPubMed
32.
Ellison DW, Kocak M, Figarella-Branger D, Felice G, Catherine G, Pietsch T, Frappaz D, Massimino M, Grill J, Boyett JM, Grundy RG. Histopathological grading of pediatric ependymoma: Reproducibility and clinical relevance in European trial cohorts. J Negat Results Biomed. 2011;10:7.CrossRefPubMedPubMedCentral
33.
Hubner JM, Kool M, Pfister SM, Pajtler KW. Epidemiology, molecular classification and WHO grading of ependymoma. J Neurosurg Sci. 2018;62:46–50.PubMed
34.
Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F, Wani K, Tatevossian R, Punchihewa C, Johann P, Reimand J, Warnatz HJ, Ryzhova M, Mack S, Ramaswamy V, Capper D, Schweizer L, Sieber L, Wittmann A, Huang Z, van Sluis P, Volckmann R, Koster J, Versteeg R, Fults D, Toledano H, Avigad S, Hoffman LM, Donson AM, Foreman N, Hewer E, Zitterbart K, Gilbert M, Armstrong TS, Gupta N, Allen JC, Karajannis MA, Zagzag D, Hasselblatt M, Kulozik AE, Witt O, Collins VP, von Hoff K, Rutkowski S, Pietsch T, Bader G, Yaspo ML, von Deimling A, Lichter P, Taylor MD, Gilbertson R, Ellison DW, Aldape K, Korshunov A, Kool M, Pfister SM. Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups. Cancer Cell. 2015;27:728–43.CrossRefPubMedPubMedCentral
35.
Capper D, Weissert S, Balss J, Habel A, Meyer J, Jäger D, Ackermann U, Tessmer C, Korshunov A, Zentgraf H, Hartmann C, von Deimling A. Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol. 2010;20:245–54.CrossRefPubMed
Metadata
Title
Freiburg Neuropathology Case Conference
Posterior Fossa Mass in an Infant
Authors
C. A. Taschner
D. Erny
M. J. Shah
H. Urbach
U. Feige
M. Prinz
Publication date
01-03-2019
Publisher
Springer Berlin Heidelberg
Published in
Clinical Neuroradiology / Issue 1/2019
Print ISSN: 1869-1439
Electronic ISSN: 1869-1447
DOI
https://doi.org/10.1007/s00062-019-00759-3

Other articles of this Issue 1/2019

Clinical Neuroradiology 1/2019 Go to the issue

Correspondence

Osteophyte piercing of the dura

Correspondence

High Resolution MRI of Vestibulocochlear Nerve Involvement by a Posterior Fossa Ganglioglioma: Case Report and Review of Literature

Original Article

Low-Dose CCT to Exclude Contraindications to Lumbar Puncture

Original Article

B-Flow Sonography for Evaluation of Basal Cerebral Arteries in Newborns

Original Article

Computed Tomography Perfusion is a Useful Adjunct to Computed Tomography Angiography in the Diagnosis of Brain Death

Original Article

Characterization of Skull Base Lesions Using Pseudo-Continuous Arterial Spin Labeling