We investigated frequencies of HER2-low breast cancer (BC) (immunohistochemistry [IHC] 1+ or 2+ without gene amplification) before and after IHC conditions were modified in order to understand the impact of IHC staining conditions on frequencies …
Authors:
Min Chong Kim, Sun Young Kwon, Hye Ra Jung, Young Kyung Bae
Angiomyolipoma with epithelial cysts (AMLEC) is a rare variant of renal angiomyolipoma (AML). It is characterized by a conventional AML component admixed with epithelial cysts within an “ovarian-like” stroma. Mixed epithelial and stromal tumor …
Authors:
Irem Kilic, Sheila Segura, Thomas M. Ulbright, Hector Mesa
Open Access
15-05-2024 | Osteosarcoma | ORIGINAL ARTICLE
High-grade osteosarcoma, a primary malignant bone tumour, is experiencing a global increase in reported incidence with varied prevalence. Despite advances in management, which include surgery and neoadjuvant chemotherapy often an unsatisfactory …
Recently, the presence of “Stroma AReactive Invasion Front Areas” (SARIFA) has been described as a promising adverse prognostic factor in gastric cancer. However, the validity of this approach still needs to be tested. The aim of this study was to …
Authors:
Dita Ulase, Hans-Michael Behrens, Christoph Röcken
Open Access
14-05-2024 | Pathology | Original Article
Nowadays pathology laboratories are worldwide facing a digital revolution, with an increasing number of institutions adopting digital pathology (DP) and whole slide imaging solutions. Despite indeed providing novel and helpful advantages …
Authors:
Albino Eccher, Stefano Marletta, Marta Sbaraglia, Angela Guerriero, Mattia Rossi, Giovanni Gambaro, Aldo Scarpa, Angelo Paolo Dei Tos
Myoepithelial neoplasms of the skin and soft tissue still represent a confusing and somewhat controversial field in pathology as it appears that this category includes several different entities. However, recent studies have suggested that both …
Authors:
Boulos Mansour, Michele Donati, Tamás Pancsa, Petr Grossman, Petr Šteiner, Tomáš Vaněček, Kateřina Comová, Michal Michal, Michael Michal
Cyclin D1 protein-positive diffuse large B cell lymphoma (DLBCL) has an immunophenotype of CD5(−) cyclin D1(+) SOX11(−), and most cases lack a CCND1 rearrangement and have a gene expression profile of DLBCL. Rarely, cyclin D1 protein-positive …
Carcinosarcoma (CS) is an uncommon and clinically aggressive malignancy. The objective of the present study was to characterize the molecular features of CS at various anatomic locations, including serous effusions. Specimens (n = 32) consisted of …
Authors:
Ben Davidson, Arild Holth, Kristina Lindemann, Ane Gerda Zahl Eriksson, Thale Andrea Nilsen, Annette Torgunrud
In surgical pathology departments, reflex first-line techniques (RFLTs) are aimed at reducing workloads and addressing recent shortages of medical personnel. However, the impacts thereof on economic and diagnostic factors have been poorly …
Authors:
Rémi Vergara, Rudy Chouvel, Béatrice Vergier, Brigitte Le Bail, Marie-Laure Négrier-Leibreich, Geneviève Belleannée, Anne Rullier, Marion Marty
Open Access
07-05-2024 | Breast Cancer | Original Article
The proposed role of CDH1 (E-cadherin gene) methylation as a mechanism of gene inactivation in invasive lobular carcinoma (ILC) remains inconclusive. For many years, CDH1 promoter hypermethylation has been regarded as a mechanism for gene …
Authors:
Silvia González-Martínez, Viera Horvathova Kajabova, Belén Pérez-Mies, Irene Carretero-Barrio, Tamara Caniego-Casas, David Sarrió, Gema Moreno-Bueno, María Gión, José Perez-García, Javier Cortés, Bozena Smolkova, José Palacios
Lung cancer is the leading cause of cancer-related death in many developed countries, including the United States and Japan [ 1 , 2 ]. Adenocarcinoma is the most common histological subtype of lung cancer [ 3 ].
Monoclonal protein detected in the serum of asymptomatic patients is defined as monoclonal gammopathy of undetermined significance (MGUS). When associated with renal disorders, the presence of a circulating monoclonal protein (M-protein) is …
Authors:
Sanjivani Shrestha, Silvia Malvica, Samir C. Gautam, Serena Bagnasco
A 5-tier grouping of Gleason scores has recently been proposed. Studies have indicated prognostic heterogeneity within these groups. We assessed prostate cancer-specific mortality (PCSM) and all-cause mortality (ACM) for men diagnosed with Gleason …
Authors:
Lars Egevad, Chiara Micoli, Brett Delahunt, Hemamali Samaratunga, Andri Wilberg Orrason, Hans Garmo, Pär Stattin, Martin Eklund
Gastroblastoma is an extremely rare gastric tumor characterized by an epithelio-mesenchymal biphasic morphology with recurrent MALAT1::GLI1 or ACTB::GLI1 gene fusion and clinically indolent behavior [ 1 – 4 ]. Although recent molecular diagnostic …
Pagetoid spread in esophageal squamous epithelium associated with underlying esophageal adenocarcinoma (EAC) has been well studied. Case reports describing pagetoid spread of esophageal squamous cell carcinomas (ESCC) also exist in the literature.
Authors:
Tiffany R. Miller, Xuchen Zhang, Huaibin M. Ko, Stephen M. Lagana, Namrata Setia, Lindsay Yassan, Maria Westerhoff, Vikram Deshpande, Jason L. Hornick, Mark S. Redston, Lei Zhao
Open Access
20-04-2024 | Metastasis | ORIGINAL ARTICLE
Leiomyoma is the most prevalent benign tumor of the female reproductive system. Benign metastasizing leiomyoma (BML) is a rare phenomenon that presents at distant sites, typically the lungs, exhibiting histopathological features similar to the …
Authors:
Xiaoxue Yin, Xiaoxia Wei, Ruqaiya Al Shamsi, Fatima S. Ali, Faiza Al Kindi, Xingming Zhang, Jiayu Liang, Xiuyi Pan, Mohammed Al Masqari, Linmao Zheng, Qiao Zhou, Abbas Agaimy, Ni Chen
Linea Melchior, Astrid Hirschmann, Paul Hofman, Christophe Bontoux, Angel Concha, Salima Mrabet‑Dahbi, Pascal Vannuffel, Emmanuel Watkin, Martina Putzová, Stefania Scarpino, Anne Cayre, Paloma Martin, Robert Stoehr, Arndt Hartmann
Somatic and biallelic DICER1 mutations are reported in subsets of thyroid tumors, supporting the role of this gene in thyroid tumor development. As recent studies have brought attention to macrofollicular patterns, atrophic changes, and papillary …
Authors:
Vincenzo Condello, James W. Roberts, Adam Stenman, Catharina Larsson, Kartik Viswanathan, C. Christofer Juhlin
Primary squamous cell carcinoma of the parotid gland (pSCCP) has long been recognized as a separate entity and is included in the WHO classifications of salivary gland tumors. However, it is widely accepted among head and neck pathologists that …
Authors:
Patrick J. Bradley, Göran Stenman, Lester D. R. Thompson, Alena Skálová, Roderick H. W. Simpson, Pieter J. Slootweg, Alessandro Franchi, Nina Zidar, Alfons Nadal, Henrik Hellquist, Michelle D. Williams, Ilmo Leivo, Abbas Agaimy, Alfio Ferlito
