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29-04-2024 | BRIEF REPORT

Gastric mesenchymal tumor with gastroblastoma-like features harboring PTCH1::GLI2 fusion

Authors: Takahiro Shibayama, Akimasa Hayashi, Nobutsugu Abe, Atsuko Ohki, Kaishi Satomi, Junji Shibahara

Excerpt

Gastroblastoma is an extremely rare gastric tumor characterized by an epithelio-mesenchymal biphasic morphology with recurrent MALAT1::GLI1 or ACTB::GLI1 gene fusion and clinically indolent behavior [1‐4]. Although recent molecular diagnostic advances have elucidated novel fusion gene other than GLI1 rearrangement, including GLI2::PTCH1 and EWSR1::CTBP1 in a single gastric tumor case diagnosed as “gastroblastoma,” respectively [5‐7], the pathogenesis of this neoplasm remains unclear. Herein, we report a gastric mesenchymal tumor with GLI2::PTCH1 gene fusion displaying overlapping morphological features and molecular background with gastroblastoma, but lacking genuine epithelial differentiation on histological and immunohistochemical grounds. An accurate distinction between gastroblastoma and a minor subset of gastric mesenchymal neoplasms with gastroblastoma-like biphasic features poses a diagnostic challenge. …

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Title: Gastric mesenchymal tumor with gastroblastoma-like features harboring PTCH1::GLI2 fusion
Authors: Takahiro Shibayama
Akimasa Hayashi
Nobutsugu Abe
Atsuko Ohki
Kaishi Satomi
Junji Shibahara
Publication date: 29-04-2024
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-024-03812-w

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Gastric mesenchymal tumor with gastroblastoma-like features harboring PTCH1::GLI2 fusion

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