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Dermatology and Therapy OnlineFirst articles

Integrative Proteomics and Genomics Identify Novel Biomarkers and Therapeutic Targets in Vitiligo via Mendelian Randomization

  • Open Access
  • Original Research

This article is published with digital features, including a graphical abstract to facilitate understanding of the article. To view digital features for this article go to https://doi.org/10.6084/m9.figshare.29104772 …

Diffusion Characteristics of LetibotulinumtoxinA, OnabotulinumtoxinA, and AbobotulinumtoxinA and its Impact on Muscle Relaxation: A Randomized Split-Face Clinical Trial

The field of aesthetic medicine has gained increasing influence in recent years [ 1 , 2 ]. According to the International Society of Aesthetic Plastic Surgery, injections with botulinumtoxinA (BoNTA) are not only the most frequently performed …

Effect of a Photolyase-Based Medical Device on Actinic Keratosis in Phototypes III–IV Patients: Real-Life Clinical Setting

AK are precancerous intraepithelial neoplasias formed by atypical proliferation of keratinocytes induced mainly by ultraviolet radiation (UVR), common in photo-exposed areas in adults, older people, and fair-skinned individuals [ 1 , 2 ]. AK are …

Investigation of the Efficacy and Safety of Xeligekimab (GR1501) in Patients with Moderate-to-Severe Plaque Psoriasis: A Multicenter, Randomized, Double-Blind Phase II Clinical

Psoriasis is a chronic, immune-mediated inflammatory skin disease with a global prevalence of approximately 2–3% [ 1 ]. According to the latest Global Burden of Disease (GBD 2019) study, the prevalence of psoriasis in China is about 0.56%, making …

Scalp Microbiome Dynamics Can Contribute to the Clinical Effect of a Novel Antiseborrheic Dermatitis Shampoo Containing Patented Antifungal Actives: A Randomized Controlled Study

Seborrheic dermatitis (SD) is a common and recurrent chronic inflammatory skin condition affecting areas rich in sebaceous glands, such as the scalp, face, upper chest, and back [ 1 ]. It affects approximately 1–5% of adults worldwide [ 2 , 3 ] and …

Oral Supplementation with a New Hyaluronic Acid Matrix Ingredient Improves Skin Brightness, Hydration, Smoothness, and Roughness: Results from a Randomized, Double-Blinded, Placebo-Controlled Study

Human skin, like other organs, ages naturally, causing changes in its appearance and function. The aging process involves a decrease in the production of essential molecules such as hyaluronic acid (HA), sulfated glycosaminoglycans (GAGs) …

Patient-Reported Outcomes by Baseline Body Surface Area Involvement Among Individuals Initiating Biologic Therapy: Results from the CorEvitas Psoriasis Registry

Psoriasis is a chronic, immune-mediated, inflammatory disease that affects approximately 3% of the US adult population [ 1 ]. The disease burden of psoriasis can vary according to factors including anatomical location of plaques (e.g., face, scalp …

Real‑World Experience of 1 Year of Tralokinumab Treatment in Adult Patients with Atopic Dermatitis: A Single-Center Retrospective Study

Atopic dermatitis (AD) is a chronic inflammatory skin disease that negatively impacts patients’ quality of life and requires long-term disease management [ 1 , 2 ]. Multiple therapeutic options exist for patients with moderate-to-severe AD …

Real-World Effectiveness and Safety of Dupilumab, Tralokinumab, and Upadacitinib in Patients with Atopic Dermatitis: A 52-Week International, Multicenter Retrospective Cohort Study

While novel targeted biologic and non-biologic therapies have demonstrated significant efficacy and favorable safety profile in controlled clinical trials for atopic dermatitis (AD) [ 1 ], evaluating their real-world performance in broader, more …

Rapid Itch Improvement and Skin Clearance with Upadacitinib Versus Placebo (Measure Up 1 and Measure Up 2) and Versus Dupilumab (Heads Up): Results from Three Phase 3 Clinical Trials in Patients with Moderate-to-Severe Atopic Dermatitis

Atopic dermatitis (AD) is one of the most prevalent chronic inflammatory skin diseases and affects 15–20% of children and up to 10% of adults worldwide [ 1 ], including 7.3% of the US adult population [ 2 ]. Skin manifestations (including redness …

Deucravacitinib in Patients with Plaque Psoriasis Who Screened Positive for Psoriatic Arthritis: Improvements in Joint Pain and the Impact of Musculoskeletal Symptoms

This article is published with digital features, including a graphical abstract to facilitate understanding of the article. To view digital features for this article go to https://doi.org/10.6084/m9.figshare.28740581 .

Tildrakizumab Treatment Patterns in Adults With Moderate-to-Severe Plaque Psoriasis: A Retrospective Analysis From the Canadian Patient Support Program

Psoriasis is a chronic, immune-mediated inflammatory skin disease affecting approximately 0.5%–11.4% of adults worldwide, including 3.4% (95% confidence interval, 2.2%–4.9%) of adults in Canada [ 1 – 3 ]. The chronic nature of plaque psoriasis …

Real-World Clinical Experience of Tralokinumab in a Tertiary Centre: An Alternative for Patients with Conjunctivitis on Dupilumab?

Tralokinumab, a human IgG4 monoclonal antibody that inhibits the IL-13 pathway, is approved for the treatment of moderate-to-severe atopic dermatitis. Phase III randomized, placebo-controlled, clinical trials (ECZTRA 1 and 2) demonstrated …

Demographics, Clinical Characteristics, and Treatment Patterns in Patients with Psoriasis: Insights from the Saudi Arabia Psoriasis Registry (PSORSA)

Psoriasis is a chronic inflammatory skin disorder that affects approximately 2% to 3% worldwide [ 1 , 2 ]. The estimated prevalence of psoriasis in the Saudi population is 5.33%. [ 3 ]. It is an immune-mediated disorder that manifests as …