Frontal fibrosing alopecia (FFA) represents a distinctive form of primary lymphocytic scarring alopecia characterized by fronto-temporal hair recession and eyebrow hair loss. While predominantly affecting postmenopausal women, FFA also occurs in …
A. Pinter, A. Costanzo, S. Khattri, S. D. Smith, J. M. Carrascosa, Y. Tada, E. Riedl, A. Reich, A. Brnabic, N. Haustrup, A. Lampropoulou, I. Lipkovich, Z. Kadziola, C. Paul, C. Schuster
Atopic dermatitis (AD) is a highly heterogeneous chronic inflammatory skin disorder that is frequently associated with a plethora of comorbidities. AD is, therefore, considered a systemic disease impacted by a considerable burden and leading to …
Authors:
Paolo Amerio, Silvia Mariel Ferrucci, Marco Galluzzo, Maddalena Napolitano, Alessandra Narcisi, Anna Levi, Sara Di Fino, Chiara Palladino, Cataldo Patruno, Mariateresa Rossi
Psoriatic arthritis (PsA) is a chronic inflammatory disease of the joints and tendons, typically associated with psoriasis of the skin and nails [ 1 ]. Approximately 20–30% of patients with psoriasis develop PsA, with the risk of developing PsA …
Authors:
April W. Armstrong, Tarannum Jaleel, Joseph F. Merola, Alice B. Gottlieb, Saakshi Khattri, Cameron C. Helt, William N. Malatestinic, Sarah E. Ross, Marcus E. Ngantcha, Kurt de Vlam
In the UPLIFT survey of patients with psoriasis and/or psoriatic arthritis in Japan, approximately 43% of patients with limited skin involvement (body surface area [BSA] ≤ 3%) self-reported moderate or severe disease [ 1 ]. Most patients with …
Erythrodermic psoriasis (EP) is the least common but a severe type of psoriasis [ 1 ]. EP is characterized by erythema and scaling that affects more than 75% of the body surface area (BSA) [ 2 ] and is difficult to cure; multiple failed treatment …
Plaque psoriasis is a common, often debilitating, chronic autoimmune inflammatory disease [ 1 ]. It has an incidence of 521.1 per 100,000 person years and, among adults, a lifetime prevalence of 2.2% in Germany [ 2 , 3 ]. According to the European …
Authors:
Andreas Pinter, Ahmed M. Soliman, Karina C. Manz, Valeria Weber, Paul Ludwig, Anja Mocek, Ariane Höer, Mark G. Lebwohl
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by itch, eczema, excoriations, and lichenification of the skin [ 1 , 2 ]. Standard practice has largely approached AD as a monolithic disease [ 3 ]; however, the clinical …
Conventional immunosuppressants such as corticosteroids, cyclosporine, methotrexate, or azathioprine present a significant burden of side effects (AEs) [ 1 ], including cytopenias (methotrexate or azathioprine), renal dysfunction or hypertension …
Chronic spontaneous urticaria (CSU) is an unpredictable inflammatory skin condition characterized by the spontaneous onset of itchy wheals, angioedema, or both, which occurs for longer than 6 weeks overall. Despite the relatively straightforward …
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening conditions that belong to the same disease spectrum. Clinically, they are characterized by widespread erythematous targetoid plaques accompanied by …
Vitiligo is a chronic autoimmune disease of the skin that targets melanocytes, causing patches of skin depigmentation [ 1 ]. The diagnosed prevalence of vitiligo is estimated to be approximately 0.1–1.5% of the US population (approximately 1.9 …
Authors:
David Rosmarin, Jennifer H. Lofland, Simran Marwaha, James Piercy, Peter Anderson, Jinan Liu
Open Access
15-05-2024 | Ixekizumab | Brief Report
Psoriasis is an inflammatory skin disease that affects up to 2–3% of the worldwide population [ 1 ]. Psoriasis is considered a systemic disease that not only affects the skin but is often associated with several comorbidities, in particular …
Authors:
Mario Valenti, Luigi Gargiulo, Luciano Ibba, Piergiorgio Malagoli, Fabrizio Amoruso, Anna Balato, Federico Bardazzi, Martina Burlando, Carlo G. Carrera, Paolo Dapavo, Valentina Dini, Francesca M. Gaiani, Giampiero Girolomoni, Claudio Guarneri, Claudia Lasagni, Francesco Loconsole, Angelo V. Marzano, Martina Maurelli, Matteo Megna, Diego Orsini, Massimo Travaglini, Antonio Costanzo, Alessandra Narcisi
Actinic keratosis (AK) is a cutaneous intraepithelial neoplasm commonly arising in sun-exposed areas among adults, particularly on the face, scalp, and dorsal hands of predisposed individuals over the age of 40 [ 1 ]. Risk factors include older …
Authors:
Federica Li Pomi, Lucia Peterle, Andrea d’Aloja, Antonio Di Tano, Mario Vaccaro, Francesco Borgia
Enthesitis and dactylitis are common periarticular manifestations and are considered the cardinal musculoskeletal lesions in early active psoriatic arthritis (PsA) [ 1 – 3 ]. The worldwide prevalence of enthesitis and dactylitis in patients with …
Authors:
Shawn G. Kwatra, Saakshi Khattri, Ahmad Z. Amin, Roberto Ranza, Blair Kaplan, Linyu Shi, Byron Padilla, Ahmed M. Soliman, Dennis McGonagle
Psoriasis is a chronic inflammatory skin disease that is estimated to affect up to 125 million people worldwide, up to one-third of whom will develop psoriatic arthritis [ 1 – 3 ]. The condition affects both males and females, although presentation …
Authors:
Anthony Bewley, Lauren Hiribarne, Jordi Galván, Sicily Mburu
The development of biologic therapies has transformed the treatment of moderate-to-severe psoriasis (PsO) [ 1 , 2 ]. Yet, the chronic nature of psoriasis necessitates more studies showing the comparative effectiveness of biologics over longer …
Authors:
A. Pinter, A. Costanzo, S. Khattri, S. D. Smith, J. M. Carrascosa, Y. Tada, E. Riedl, A. Reich, A. Brnabic, N. Haustrup, A. Lampropoulou, I. Lipkovich, Z. Kadziola, C. Paul, C. Schuster
