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Open Access 02-05-2024 | Inflammatory Rheumatic Diseases | Review

Uncovering the link between inflammatory rheumatic diseases and male reproductive health: a perspective on male infertility and sexual dysfunction

Authors: Marlen Yessirkepov, Burhan Fatih Kocyigit, Kairat Zhakipbekov, Erbolat Adilbekov, Kassymkhan Sultanbekov, Mazlum Serdar Akaltun

Published in: Rheumatology International

Abstract

Inflammatory rheumatic diseases (IRDs) refer to a range of persistent disorders that have a major influence on several physiological systems. Although there is much evidence connecting IRDs to sexual dysfunction and fertility problems, research specifically focusing on male infertility in relation to these diseases is sparse. This review addresses the complicated connection between IRDs and male infertility, emphasising the physiological, psychological, and pharmacological aspects that influence reproductive health outcomes in men with rheumatic conditions. We explore the effects of IRDs and their treatments on many facets of male reproductive well-being, encompassing sexual functionality, semen characteristics, and hormonal balance. Additionally, we present a comprehensive analysis of the present knowledge on the impact of several categories of anti-rheumatic drugs on male reproductive function. Although there is an increasing awareness of the need of addressing reproductive concerns in individuals IRDs, there is a noticeable lack of research especially dedicated to male infertility. Moving forward, more comprehensive research is needed to determine the prevalence, risk factors, and mechanisms driving reproductive difficulties in males with IRDs. We can better assist the reproductive health requirements of male IRD patients by expanding our understanding of male infertility in the setting of rheumatic disorders and implementing holistic methods to care.

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Title: Uncovering the link between inflammatory rheumatic diseases and male reproductive health: a perspective on male infertility and sexual dysfunction
Authors: Marlen Yessirkepov
Burhan Fatih Kocyigit
Kairat Zhakipbekov
Erbolat Adilbekov
Kassymkhan Sultanbekov
Mazlum Serdar Akaltun
Publication date: 02-05-2024
Publisher: Springer Berlin Heidelberg
Keywords: Inflammatory Rheumatic Diseases
Infertility
Erectile Dysfunction
Varicocele
Systemic Lupus Erythematosus
Ankylosing Spondylitis
Familial Mediterranean Fever
Systemic Sclerosis
Published in: Rheumatology International
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-024-05602-8

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