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01-09-2008 | Basic Neurosciences, Genetics and Immunology - Short Communication

Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans

Authors: Vittorio Coiro, Gloria Saccani-Jotti, Pasquale Rubino, Guido Manfredi, Paola Vacca, Elio Volta, Paolo Chiodera

Published in: Journal of Neural Transmission | Issue 9/2008

Abstract

Oxytocin (OT) effect on ghrelin-stimulated neuropeptide Y (NPY) secretion was evaluated in 12 normal men. Tests: ghrelin (1 μg/kg B.W. as an intravenous bolus); OT (2 mIU/min infusion); ghrelin plus OT; normal saline. Plasma NPY did not change during saline or OT infusions, whereas it showed a significant 29% increase vs baseline at 15 min after ghrelin injection. When OT was present, ghrelin-induced NPY increment was completely abolished. Results show that oxytocin modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels.

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Title: Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans
Authors: Vittorio Coiro
Gloria Saccani-Jotti
Pasquale Rubino
Guido Manfredi
Paola Vacca
Elio Volta
Paolo Chiodera
Publication date: 01-09-2008
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 9/2008
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0057-0

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Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans

Abstract

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Abstract

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