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Clinical Reviews in Allergy & Immunology

Published in:

15-01-2022

Immunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases

Authors: Augusto Bleve, Francesca Motta, Barbara Durante, Chiara Pandolfo, Carlo Selmi, Antonio Sica

Published in: Clinical Reviews in Allergy & Immunology | Issue 2/2023

Abstract

The immune system is the central regulator of tissue homeostasis, ensuring tissue regeneration and protection against both pathogens and the neoformation of cancer cells. Its proper functioning requires homeostatic properties, which are maintained by an adequate balance of myeloid and lymphoid responses. Aging progressively undermines this ability and compromises the correct activation of immune responses, as well as the resolution of the inflammatory response. A subclinical syndrome of “homeostatic frailty” appears as a distinctive trait of the elderly, which predisposes to immune debilitation and chronic low-grade inflammation (inflammaging), causing the uncontrolled development of chronic and degenerative diseases. The innate immune compartment, in particular, undergoes to a sequela of age-dependent functional alterations, encompassing steps of myeloid progenitor differentiation and altered responses to endogenous and exogenous threats. Here, we will review the age-dependent evolution of myeloid populations, as well as their impact on frailty and diseases of the elderly.

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Title: Immunosenescence, Inflammaging, and Frailty: Role of Myeloid Cells in Age-Related Diseases
Authors: Augusto Bleve
Francesca Motta
Barbara Durante
Chiara Pandolfo
Carlo Selmi
Antonio Sica
Publication date: 15-01-2022
Publisher: Springer US
Published in: Clinical Reviews in Allergy & Immunology / Issue 2/2023
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-021-08909-7

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