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Published in: BMC Complementary Medicine and Therapies 1/2021

01-12-2021 | Hypertension | Study protocol

The effectiveness and safety of Tai Chi for patients with essential hypertension: study protocol for an open-label single-center randomized controlled trial

Authors: Yuxi Li, Dongling Zhong, Chao Dong, Lihong Shi, Yaling Zheng, Yongguo Liu, Qiaoqin Li, Hui Zheng, Juan Li, Tianyu Liu, Rongjiang Jin

Published in: BMC Complementary Medicine and Therapies | Issue 1/2021

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Abstract

Background

Evidence showed that Tai Chi may have beneficial effects among hypertensive individuals, although the results are not convincing. We aim to conduct a high-quality clinical trial with 24-h BP measurement to provide robust evidence of Tai Chi for essential hypertension.

Methods

This is an open-label single-center randomized controlled trial with 3 parallel arms. We will compare Tai Chi with walking and waiting-list control. We will recruit 234 hypertensive patients with mild to moderate essential hypertension and randomly assign them to 3 different groups. Participants in Tai Chi group will receive a group-format Yang style 24-form Tai Chi exercise program, 3 sessions per week for 12 weeks. The walking group will be asked to walk, 3 sessions per week for 12 weeks. The waiting-list group will not receive any interventions and/or exercise training. The primary outcome is the change in average 24-h systolic blood pressure (SBP) between baseline and 12 weeks after randomization. The secondary outcomes include 24-h Diastolic Blood Pressure (DBP), average SBP and average DBP during the daytime and night-time, blood pressure (BP) variability, SBP load and DBP load, circadian rhythm of BP, and morning BP surge, endothelial functional indicators, home measured BP, quality of life, adverse events and so on.

Discussion

We expect findings of this trial will provide important insight into application of Tai Chi as an effective and acceptable method for hypertensive patients. Successful completion of this proposed study will also contribute to promotion of Tai Chi in the community in the future.

Trial registration

Clinicaltrials.gov registry: https://​clinicaltrials.​gov/​ct2/​show/​NCT04267471, date: February 12, 2020.
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Metadata
Title
The effectiveness and safety of Tai Chi for patients with essential hypertension: study protocol for an open-label single-center randomized controlled trial
Authors
Yuxi Li
Dongling Zhong
Chao Dong
Lihong Shi
Yaling Zheng
Yongguo Liu
Qiaoqin Li
Hui Zheng
Juan Li
Tianyu Liu
Rongjiang Jin
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2021
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-020-03192-z

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