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BMC Complementary Medicine and Therapies

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Open Access 01-12-2021 | Hypertension | Research

Ameliorated biomechanical properties of carotid arteries by puerarin in spontaneously hypertensive rats

Authors: Xiaoxia Fang, Sheng Dong, Yun Wu, Yun He, Min Lu, Dandan Shi, Na Feng, Songhe Yin, Yan Jiang, Anhua Zhang, Yan Ding, Qiufang Zhang, Junming Tang, Wenjun Zhang, Xiju He

Published in: BMC Complementary Medicine and Therapies | Issue 1/2021

Abstract

Background

An emerging body of evidence indicates that puerarin (PUE) plays an important role in the treatment of angina pectoris, myocardial ischemia-reperfusion injury, hypertension and other cardiovascular diseases, but how PUE affects the vascular remodeling of hypertensive rats has not been reported yet. This study aimed to investigate the effect and mechanism of PUE on carotid arteries of spontaneously hypertensive rats (SHR) to provide the basis for the clinical application of PUE.

Methods

Thirty male SHR and six male Wistar Kyoto rats (WKY) aged 3 months were used in this study, SHR rats were randomly divided into 5 groups, PUE(40 or 80 mg/kg/d, ip) and telmisartan (TELMI) (30 mg/kg/d, ig) were administrated for 3 months. We use DMT myography pressure-diameter system to investigate biomechanical properties of carotid arteries, 10 μM pan-classical transient receptor potential channels (TRPCs) inhibitor SKF96365, 200 nM specific TRPC6 inhibitor SAR7334 and 100 μM Orai1 inhibitor ANCOA4 were used in the mechanical test.

Results

PUE can significantly decrease systolic and diastolic blood pressure, long-term administration of PUE resulted in a mild reduction of thickness and inner diameter of carotid artery. PUE ameliorate NE-response and vascular remodeling mainly through inhibiting TRPCs channel activities of VSMC.

Conclusion

PUE can ameliorate biomechanical remodeling of carotid arteries through inhibiting TRPCs channel activities of VSMC in spontaneously hypertensive rats.

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Title: Ameliorated biomechanical properties of carotid arteries by puerarin in spontaneously hypertensive rats
Authors: Xiaoxia Fang
Sheng Dong
Yun Wu
Yun He
Min Lu
Dandan Shi
Na Feng
Songhe Yin
Yan Jiang
Anhua Zhang
Yan Ding
Qiufang Zhang
Junming Tang
Wenjun Zhang
Xiju He
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Hypertension
Hypertension
Published in: BMC Complementary Medicine and Therapies / Issue 1/2021
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/s12906-021-03345-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Ameliorated biomechanical properties of carotid arteries by puerarin in spontaneously hypertensive rats

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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