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Published in: Inflammation 2/2019

01-04-2019 | ORIGINAL ARTICLE

Hydrogen-Rich Saline Ameliorates Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice Via the Nrf2-ARE Signaling Pathway

Authors: Yaping Liu, Fuxing Dong, Rui Guo, Ying Zhang, Xuebin Qu, Xiuxiang Wu, Ruiqin Yao

Published in: Inflammation | Issue 2/2019

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Abstract

Multiple sclerosis (MS) is a chronic and inflammatory disease of the central nervous system that is associated with demyelination, neurodegeneration, and sensitivity to oxidative stress. Hydrogen-rich saline (HRS) is efficacious in preventive and therapeutic applications for many disorders because of its antioxidant and anti-inflammatory properties. Here, we determined the effect of HRS in experimental autoimmune encephalomyelitis (EAE), which is a generally accepted model of the immuno-pathogenic mechanisms underlying MS. We found that HRS reduced the severity of EAE in mice and alleviated inflammation and demyelination. Furthermore, treatment with HRS attenuated oxidative stress in EAE mice. Finally, the results of our study suggest that activation of the Nrf2-ARE pathway plays a critical role in the protective effects of HRS in EAE mice.
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Metadata
Title
Hydrogen-Rich Saline Ameliorates Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice Via the Nrf2-ARE Signaling Pathway
Authors
Yaping Liu
Fuxing Dong
Rui Guo
Ying Zhang
Xuebin Qu
Xiuxiang Wu
Ruiqin Yao
Publication date
01-04-2019
Publisher
Springer US
Published in
Inflammation / Issue 2/2019
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-018-0915-3

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