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Inflammation
Published in: Inflammation 2/2019

01-04-2019 | ORIGINAL ARTICLE

Gasdermin-d Played a Critical Role in the Cyclic Stretch–Induced Inflammatory Reaction in Human Periodontal Ligament Cells

Authors: Jiabao Zhuang, Yingying Wang, Fang Qu, Yaqin Wu, Dan Zhao, Chun Xu

Published in: Inflammation | Issue 2/2019

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Abstract

It has been shown that cyclic stretch could induce inflammatory response such as pyroptosis and the release of IL-1β in human periodontal ligament cells, through activating inflammasome and related caspases. Though gasdermin-d (GSDMD) has been reported to be present in some inflammatory diseases and function as a crucial executioner of pyroptosis, the role of GSDMD in the stretch-induced inflammatory response in human periodontal ligament cells (HPDLCs) has not been well clarified. In this study, it was found that GSDMD was activated by cyclic stretch, and its activation affected the pyroptotic rate in HPDLCs, leading to the maturation and secretion of IL-1β and IL-18 ultimately. In addition, GSDMD was found to be regulated by caspase-1 directly. Nevertheless, the exact relationship between inflammasomes and GSDMD in the stretch-induced inflammatory response still needs to be further elucidated.
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Metadata
Title
Gasdermin-d Played a Critical Role in the Cyclic Stretch–Induced Inflammatory Reaction in Human Periodontal Ligament Cells
Authors
Jiabao Zhuang
Yingying Wang
Fang Qu
Yaqin Wu
Dan Zhao
Chun Xu
Publication date
01-04-2019
Publisher
Springer US
Published in
Inflammation / Issue 2/2019
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-018-0912-6

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