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European Journal of Clinical Microbiology & Infectious Diseases

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01-01-2020 | Herpes Virus | Review

Melittin: a venom-derived peptide with promising anti-viral properties

Authors: Hamed Memariani, Mojtaba Memariani, Hamideh Moravvej, Mohammad Shahidi-Dadras

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 1/2020

Abstract

Despite tremendous advances in the development of anti-viral therapeutics, viral infections remain a chief culprit accounting for ongoing morbidity and mortality worldwide. Natural products, in particular animal venoms, embody a veritable cornucopia of exotic constituents, suggesting an immensurable source of anti-infective drugs. In this context, melittin, the principal constituent in the venom of the European honeybee Apis mellifera, has been demonstrated to exert anti-cancer, anti-inflammatory, anti-diabetic, anti-infective, and adjuvant properties. To our knowledge, there is no review appertaining to effects of melittin against viruses, prompting us to synopsize experimental investigations on its anti-viral activity throughout the past decades. Accumulating evidence indicates that melittin curbs infectivity of a diverse array of viruses including coxsackievirus, enterovirus, influenza A viruses, human immunodeficiency virus (HIV), herpes simplex virus (HSV), Junín virus (JV), respiratory syncytial virus (RSV), vesicular stomatitis virus (VSV), and tobacco mosaic virus (TMV). However, medication safety, different routes of administrations, and molecular mechanisms behind the anti-viral activity of melittin should be scrutinized in future studies.

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Title: Melittin: a venom-derived peptide with promising anti-viral properties
Authors: Hamed Memariani
Mojtaba Memariani
Hamideh Moravvej
Mohammad Shahidi-Dadras
Publication date: 01-01-2020
Publisher: Springer Berlin Heidelberg
Keywords: Herpes Virus
Respiratory Syncytial Virus Infection
Herpes Simplex Type 1
Human Immunodeficiency Virus
Influenza
Published in: European Journal of Clinical Microbiology & Infectious Diseases / Issue 1/2020
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-019-03674-0

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

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Abstract

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At a glance: The STEP trials