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Hepatology International
Published in: Hepatology International 3/2020

01-05-2020 | Hepatitis B | Editorial

Stopping oral antiviral treatment to cure chronic hepatitis B, is it in sight?

Authors: Rong Fan, Jinlin Hou

Published in: Hepatology International | Issue 3/2020

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Excerpt

The treatment of chronic hepatitis B (CHB) patients has evolved dramatically over the past two decades. Currently, oral nucleos(t)ide analogues (NA) with potent viral suppression and a high genetic barrier to resistance, i.e., entecavir, tenofovir disoproxil and tenofovir alafenamide, are recommended as first-line antivirals. Long-term NA treatment can suppress hepatitis B virus (HBV) replication, reverse liver fibrosis, and reduce the risk of hepatocellular carcinoma (HCC) [1]. …
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Hadziyannis SJ, Sevastianos V, Rapti I, et al. Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stop long-term treatment with adefovir. Gastroenterology 2012;143:629–636
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Berg T, Simon KG, Mauss S, et al. Long-term response after stopping tenofovir disoproxil fumarate in non-cirrhotic HBeAg-negative patients—FINITE study. J Hepatol 2017;67:918–924CrossRef
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Jeng W-J, Chen Y-C, Chien R-N, et al. Incidence and predictors of hepatitis B surface antigen seroclearance after cessation of nucleos(t)ide analogue therapy in hepatitis B e antigen–negative chronic hepatitis B. Hepatology 2018;68:425–434CrossRef
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Liem KS, Fung S, Wong DK, et al. Limited sustained response after stopping nucleos(t)ide analogues in patients with chronic hepatitis B: results from a randomised controlled trial (Toronto STOP study). Gut 2019;68:2206–2213CrossRef
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Buti M, Wong DK, Gane E, et al. Safety and efficacy of stopping tenofovir disoproxil fumarate in patients with chronic hepatitis B following at least 8 years of therapy: a prespecified follow-up analysis of two randomised trials. Lancet Gastroenterol Hepatol 2019;4:296–304CrossRef
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Papatheodoridis G, Vlachogiannakos I, Cholongitas E, et al. Discontinuation of oral antivirals in chronic hepatitis B: a systematic review. Hepatology 2016;63:1481–1492CrossRef
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Hsu YC, Nguyen MH, Mo LR, et al. Combining hepatitis B core-related and surface antigens at end of nucleos(t)ide analogue treatment to predict off-therapy relapse risk. Aliment Pharmacol Ther 2019;49:107–115CrossRef
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Metadata
Title
Stopping oral antiviral treatment to cure chronic hepatitis B, is it in sight?
Authors
Rong Fan
Jinlin Hou
Publication date
01-05-2020
Publisher
Springer India
Published in
Hepatology International / Issue 3/2020
Print ISSN: 1936-0533
Electronic ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-020-10039-9

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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