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07-02-2023 | Hepatitis B | Original Article

A Comparative Trial of Improving Care for Underserved Asian Americans Infected with Hepatitis B Virus

Authors: Grace X. Ma, Lin Zhu, Yin Tan, Shumenghui Zhai, Xiaoli Ma, Olorunseun O. Ogunwobi, Wei Jenny Yang, Tsunyou Ting, Sara Kim, Min Qi Wang

Published in: Digestive Diseases and Sciences | Issue 6/2023

Abstract

Background

Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC). Asian Americans have the highest incidence and mortality rates of HCC among all US racial/ethnic groups. Inadequate monitoring and treatment of chronic hepatitis B contribute to poor health outcomes and increased healthcare costs among Asian Americans.

Aims

The goal of this study is to assess the effect of a patient-led strategy on chronic hepatitis B monitoring and treatment adherence specifically among Asian Americans with culturally tailored Patient Navigator-led Intervention.

Methods

From 2015 to 2018, 532 eligible participants living with chronic hepatitis B in the greater Philadelphia and New York city metropolitan areas were randomly assigned to either the intervention group or the control group. Generalized linear mixed-effects models were used to estimate the odds ratio (OR) for rates of doctor visits for chronic hepatitis B and rates of alanine aminotransferase testing for evidence of liver damage.

Results

Intervention group had higher rates of doctor visits than the control group at both 6-month (77.22% vs. 45.75%) and 12-month assessments (90.73% vs. 60.61%). Significantly more intervention group participants received ALT testing than control group participants at 6-month (52.90% vs. 25.10%) and 12-month (75.40% vs. 46.75%) follow-up.

Conclusions

Culturally and linguistically appropriate intervention has strong effects on adherence to follow-up care among Asian American hepatitis B patients experiencing challenges to medication adherence and follow up care. These findings further identify opportunities for practical implementation of evidence-based intervention that could lead to reductions in disparities in chronic liver disease and liver cancer among high-risk, underserved populations.

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Title: A Comparative Trial of Improving Care for Underserved Asian Americans Infected with Hepatitis B Virus
Authors: Grace X. Ma
Lin Zhu
Yin Tan
Shumenghui Zhai
Xiaoli Ma
Olorunseun O. Ogunwobi
Wei Jenny Yang
Tsunyou Ting
Sara Kim
Min Qi Wang
Publication date: 07-02-2023
Publisher: Springer US
Keywords: Hepatitis B
Care
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Published in: Digestive Diseases and Sciences / Issue 6/2023
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-023-07840-5

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