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Hematology

Editor's Choice

Beti-cel promising for severe β-thalassemia

Gene therapy with betibeglogene autotemcel leads to high rates of transfusion independence in patients with severe transfusion-dependent β-thalassemia.

Novel CAR T-cell therapy shows potential for B-cell ALL

Obecabtagene autoleucel has demonstrated promising antitumor activity and safety in adults with relapsed or refractory B-cell acute lymphoblastic leukemia.

Menin inhibitors for AML: opportunities and challenges

Menin inhibitors are the newest addition to the acute myeloid leukemia treatment landscape. Find out more about the different agents as well as the opportunities and challenges associated with using them in clinical practice.

Lead encephalopathy from chipped paint

Public health measures mean severe lead toxicity is rare, making its recognition and management challenging. This 4-year-old presented with refractory status epilepticus and severe microcytic anemia. How would you diagnose and treat her?

Quitting smoking early after cancer diagnosis improves survival

A prospective cohort study has shown that quitting smoking after a cancer diagnosis is associated with improved survival, with the greatest benefit for those quitting within 6 months.

Atypical presentation of PJP

Typical symptoms of Pneumocystis jirovecii pneumonia include dyspnea, cough, and low-grade fever. But this patient, an allogeneic stem cell transplant recipient, presented with hypercalcemia and kidney injury.

Stroke as initial manifestation of CML progression

A patient with chronic myeloid leukemia presented with the signs and symptoms of acute ischemic stroke and was found on further evaluation to have progressed to the promyelocytic blast phase.

Pulmonary embolism in a patient with hemophilia

A woman with factor V and VIII deficiency developed a pulmonary embolism during pregnancy. Although thromboembolic events may not be the first consideration in the setting of hemophilia, this case shows they can occur.

Nivolumab outplays brentuximab vedotin in Hodgkin’s lymphoma

Adding nivolumab rather than brentuximab vedotin to the standard chemotherapy backbone for advanced-stage classic Hodgkin’s lymphoma significantly improves PFS.

Pancytopenia after parathyroid surgery

A woman with parathyroid adenoma and brown tumor developed pancytopenia following parathyroidectomy, highlighting the need to monitor blood cell counts after surgery in such patients.

Liberal vs restrictive blood transfusion strategies in ABI

Patients with acute brain injury given blood transfusions when hemoglobin levels fall below 9 g/dL are less likely to have an unfavorable neurological outcome than those restricted to transfusions at levels below 7 g/dL.

Obesity-related venous thromboembolism

Obesity is a recognized risk factor for VTE, but what is the current understanding of VTE in people living with obesity, their clinical needs, and the therapeutic challenges they face?

Managing stroke in sickle cell anemia

Sickle cell anemia increases stroke risk more than 200 fold. What are the options for primary and secondary stroke prevention and treatment in young people?

TTP after a complicated TAVR procedure

When a patient presents with hemolytic anemia, thrombocytopenia, acute renal failure or neuropsychiatric symptoms after complicated cardiac surgery, TTP should be suspected. Make sure you know how to rapidly diagnose and treat this life-threatening emergency.

Lifelong follow-up needed for children undergoing HCT for NMDs

Late toxic effects are common in children who undergo allogenic hematopoietic cell transplantation for nonmalignant diseases and therefore require lifelong follow-up.

Liquid biopsy may help predict cancer-associated VTE

Liquid biopsies could help to identify patients with cancer who have an increased risk for venous thromboembolism.

Eosinophilic cystitis in an infant

Eosinophilic cystitis is a rare, easily treatable, and important differential of bladder mass in children, which may present with an atypical obstructive uropathy.

Managing toxicities of CAR T-cell therapy

A practical guide to the diagnosis, management, and treatment of complications associated with CAR T cell-therapy, ranging from cytokine release syndrome to neurotoxicity.

Critical care of spinal cord injury

After a primary mechanical insult, acute critical care can minimize secondary injury due to ischemia and inflammation and help to avoid complications that adversely affect neurological outcome.

Liberal vs restrictive transfusion strategy for TBI

A liberal transfusion strategy does not reduce the risk for an unfavorable neurological outcome after traumatic brain injury compared with a restrictive strategy.