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European Journal of Medical Research
Published in: European Journal of Medical Research 1/2023

Open Access 01-12-2023 | Gastric Cancer | Research

Postoperative ratio of C-reactive protein to albumin is an independent prognostic factor for gastric cancer

Authors: Chenxi Li, Xuhui Yang, Hui Li, Yan Fu, Wenying Wang, Xin Jin, Lihua Bian, Liang Peng

Published in: European Journal of Medical Research | Issue 1/2023

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Objective

The role of postoperative of the ratio of c-reactive protein to albumin (CRP/Alb ratio) in the prognosis of gastric cancer is rarely evaluated. Our purpose was to investigate the correlation of the postoperative CRP/Alb ratio and long-term prognosis of gastric cancer.

Methods

We enrolled 430 patients who suffered from radical gastrectomy. The commonly used inflammatory indices, clinical-pathological characteristics and oncologic outcomes were recorded. The median was used to the cut-off value for preoperative and postoperative CRP/Alb ratio, respectively. Kaplan–Meier analysis and Cox proportional hazards regression model were performed to determine its prognostic significance.

Results

In univariate analysis, there were significant differences were observed in overall survival (OS) according to perioperative CRP/Alb ratio, c-reactive protein (CRP), serum albumin (Alb), respectively. According to the multivariate analysis, higher postoperative CRP/Alb ratio (HR 2.03, 95% CI 1.55–2.66, P < 0.001), lower postoperative albumin (Alb), higher preoperative c-reactive protein (CRP) and higher postoperative CRP were indicated a shorter overall survival.

Conclusion

Postoperative inflammatory factors in patients with gastric cancer should be pay attention, especially postoperative CRP/Alb ratio may be an independent predictor of long-term prognosis of gastric cancer.
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Metadata
Title
Postoperative ratio of C-reactive protein to albumin is an independent prognostic factor for gastric cancer
Authors
Chenxi Li
Xuhui Yang
Hui Li
Yan Fu
Wenying Wang
Xin Jin
Lihua Bian
Liang Peng
Publication date
01-12-2023
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-023-01334-w

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