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Current Nutrition Reports

Folate and Its Impact on Cancer Risk

  • Open Access
  • 01-09-2018
  • Cancer (MF Leitzmann, Section Editor)
Published in:
Authors
Renee Pieroth
Stephanie Paver
Sharon Day
Carolyn Lammersfeld
Published in
Current Nutrition Reports | Issue 3/2018

Abstract

Purpose of Review

Research has evaluated the potential impact of folate on cancer risk with conflicting findings. Studies have demonstrated increased risk, no effect, and decreased risk. This review summarizes findings of mixed results between folate intake, serum levels, gene polymorphisms, and cancer risk based on meta-analyses from the past five years.

Recent Finding

Low or deficient folate status is associated with increased risk of many cancers. Folic acid supplementation and higher serum levels are associated with increased risk of prostate cancer. Gene polymorphisms may impact risk in certain ethnic groups.

Summary

Folate has been studied extensively due to its role in methylation and nucleotide synthesis. Further prospective studies are needed to clarify optimal levels for nutrient remediation and risk reduction in those at risk, as well as elucidate the association between high intake, high serum levels, and prostate cancer risk. Future considerations for cancer risk may include gene interactions with nutrients and environmental factors.
Title
Folate and Its Impact on Cancer Risk
Authors
Renee Pieroth
Stephanie Paver
Sharon Day
Carolyn Lammersfeld
Publication date
01-09-2018
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 3/2018
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-018-0237-y
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Other articles of this Issue 3/2018

The Role of Diet in Multiple Sclerosis: Mechanistic Connections and Current Evidence

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  • Neurological Disease and Cognitive Function (Y Gu, Section Editor)

The Role of Physical Activity in Managing Fatigue in Cancer Survivors

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The Role of Nutrition in Cognitive Function and Brain Ageing in the Elderly

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Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome

  • Gastroenterology, Critical Care, and Lifestyle Medicine (SA McClave, Section Editor)

Impact of Energy Drinks on Health and Well-being

  • Gastroenterology, Critical Care, and Lifestyle Medicine (SA McClave, Section Editor)

Are We Going Nuts on Coconut Oil?

  • Gastroenterology, Critical Care, and Lifestyle Medicine (SA McClave, Section Editor)

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Keynote webinar | Spotlight on functional neurological disorder

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Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images, Human brain illustration/© (M) CHRISTOPH BURGSTEDT / SCIENCE PHOTO LIBRARY / Getty Images