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Current Nutrition Reports

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Open Access 01-09-2018 | Cancer (MF Leitzmann, Section Editor)

Folate and Its Impact on Cancer Risk

Authors: Renee Pieroth, Stephanie Paver, Sharon Day, Carolyn Lammersfeld

Published in: Current Nutrition Reports | Issue 3/2018

Abstract

Purpose of Review

Research has evaluated the potential impact of folate on cancer risk with conflicting findings. Studies have demonstrated increased risk, no effect, and decreased risk. This review summarizes findings of mixed results between folate intake, serum levels, gene polymorphisms, and cancer risk based on meta-analyses from the past five years.

Recent Finding

Low or deficient folate status is associated with increased risk of many cancers. Folic acid supplementation and higher serum levels are associated with increased risk of prostate cancer. Gene polymorphisms may impact risk in certain ethnic groups.

Summary

Folate has been studied extensively due to its role in methylation and nucleotide synthesis. Further prospective studies are needed to clarify optimal levels for nutrient remediation and risk reduction in those at risk, as well as elucidate the association between high intake, high serum levels, and prostate cancer risk. Future considerations for cancer risk may include gene interactions with nutrients and environmental factors.

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Title: Folate and Its Impact on Cancer Risk
Authors: Renee Pieroth
Stephanie Paver
Sharon Day
Carolyn Lammersfeld
Publication date: 01-09-2018
Publisher: Springer US
Published in: Current Nutrition Reports / Issue 3/2018
Electronic ISSN: 2161-3311
DOI: https://doi.org/10.1007/s13668-018-0237-y

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Abstract

Purpose of Review

Recent Finding

Summary

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