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Current Nutrition Reports

Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome

  • 01-09-2018
  • Cardiovascular Disease (JHY Wu, Section Editor)
Published in:
Authors
Edward Rojas
Valmore Bermúdez
Yasaman Motlaghzadeh
Justin Mathew
Enzamaria Fidilio
Judith Faria
Joselyn Rojas
Mayela Cabrera de Bravo
Julio Contreras
Linda Pamela Mantilla
Lissé Angarita
Paola Amar Sepúlveda
Isaac Kuzmar
Published in
Current Nutrition Reports | Issue 3/2018

Abstract

Purpose of Review

Stevia rebaudiana Bertoni is a perennial shrub with zero calorie content that has been increasing in popularity for its potential use as an adjuvant in the treatment of obesity. The level of evidence supporting general benefits to human health is insufficient. We conducted a review of the literature summarizing the current knowledge and role in human disease.

Recent Findings

Despite stevia’s minimal systemic absorption, studies have been promising regarding its potential benefits against inflammation, carcinogenesis, atherosclerosis glucose control, and hypertension. On the other hand, the growing popularity of artificial sweeteners does not correlate with improved trends in obesity. An increased intake of artificial non-caloric sweeteners may not be associated with decreased intake of traditional sugar-sweetened beverages and foods. The effects of Stevia on weight change have been linked to bacteria in the intestinal microbiome, mainly by affecting Clostridium and Bacteroides sp. populations. A growing body of evidence indicates that Stevia rebaudiana Bertoni is protective against malignant conversion by inhibition of DNA replication in human cancer cell growth in vitro.

Summary

Consumption of Stevia has demonstrated to be generally safe in most reports. Further clinical studies are warranted to determine if regular consumption brings sustained benefits for human health.
Title
Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome
Authors
Edward Rojas
Valmore Bermúdez
Yasaman Motlaghzadeh
Justin Mathew
Enzamaria Fidilio
Judith Faria
Joselyn Rojas
Mayela Cabrera de Bravo
Julio Contreras
Linda Pamela Mantilla
Lissé Angarita
Paola Amar Sepúlveda
Isaac Kuzmar
Publication date
01-09-2018
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 3/2018
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-018-0228-z
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