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Current Gastroenterology Reports
Published in: Current Gastroenterology Reports 5/2012

01-10-2012 | Large Intestine (B Cash, Section Editor)

Familial Colon Cancer Syndromes: an Update of a Rapidly Evolving Field

Authors: Swati G. Patel, Dennis J. Ahnen

Published in: Current Gastroenterology Reports | Issue 5/2012

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Abstract

Colorectal cancer (CRC) is a major cause of morbidity and mortality in the world. Up to 30 % of CRCs have evidence of a familial component, and about 5 % are thought to be due to well-characterized inherited mutations. This review will focus on recent developments in the understanding of the individual hereditary CRC syndromes, including Lynch syndrome, familial CRC type X, familial adenomatous polyposis, MutYH-associated polyposis, Peutz–Jeghers syndrome, juvenile polyposis syndrome, PTEN hamartomatous syndrome, and serrated polyposis syndrome. Advances within the area of hereditary colon cancer syndromes paint a picture of a rapidly moving, rapidly maturing, and increasingly collaborative field with many opportunities for ongoing research and development.
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Metadata
Title
Familial Colon Cancer Syndromes: an Update of a Rapidly Evolving Field
Authors
Swati G. Patel
Dennis J. Ahnen
Publication date
01-10-2012
Publisher
Current Science Inc.
Published in
Current Gastroenterology Reports / Issue 5/2012
Print ISSN: 1522-8037
Electronic ISSN: 1534-312X
DOI
https://doi.org/10.1007/s11894-012-0280-6

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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