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International Urogynecology Journal
Published in: International Urogynecology Journal 1/2020

01-01-2020 | Original Article

Evaluation of COLIA1-1997 G/T polymorphism as a related factor to genital prolapse

Authors: Claudia Cristina Palos, Beatriz Ferreira Timm, Denise de Souza Paulo, Cesar Eduardo Fernandes, Ricardo Peres de Souto, Emerson Oliveira

Published in: International Urogynecology Journal | Issue 1/2020

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Abstract

Introduction and hypothesis

Pelvic organ prolapse has a multifactorial etiology. There is increasing evidence that genetic factors greatly impact its development. This study aimed to evaluate the possible relation of the collagenous polymorphism −1997 G/T with genital prolapse in Brazilian women.

Methods

A cohort study of 180 women with stage 0 or I (group A) pelvic organ prolapse disorder and 112 women with stage III or IV (group B) was conducted. Blood DNA was isolated, and the −1997 G/T polymorphism was identified by amplifying a region of the COLIA1 gene starting prior to the protein’s coding sequence.

Results

No significant difference in the prevalence of genotypes TG and TT was found between groups (p = 0.67); differences were not found even when patients were grouped by the presence of 0 or ≥ 1 polymorphic alleles (p = 0.46). Age and home birth were found to be independent risk factors for prolapse.

Conclusions

Our study could not find any association between the −1997G/T polymorphism and genital prolapse in Brazilian women.
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Metadata
Title
Evaluation of COLIA1-1997 G/T polymorphism as a related factor to genital prolapse
Authors
Claudia Cristina Palos
Beatriz Ferreira Timm
Denise de Souza Paulo
Cesar Eduardo Fernandes
Ricardo Peres de Souto
Emerson Oliveira
Publication date
01-01-2020
Publisher
Springer International Publishing
Published in
International Urogynecology Journal / Issue 1/2020
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-018-3833-x

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