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Open Access 01-03-2012 | Original Article

Pelvic organ prolapse and collagen-associated disorders

Authors: Karin Lammers, Sabrina L. Lince, Marian A. Spath, Léon C. L. T. van Kempen, Jan C. M. Hendriks, Mark E. Vierhout, Kirsten B. Kluivers

Published in: International Urogynecology Journal | Issue 3/2012

Abstract

Introduction and hypothesis

Pelvic organ prolapse (POP) and other disorders, such as varicose veins and joint hypermobility, have been associated with changes in collagen strength and metabolism. We hypothesized that these various disorders were more prevalent in both POP patients and their family members.

Methods

In this study, the prevalence of various collagen-associated disorders, including POP, was compared between POP patients (n = 110) and control patients (n = 100) and their first and second degree family members.

Results

POP patients reported a higher prevalence of varicose veins, joint hypermobility and rectal prolapse and were more likely to have family members with POP as compared to the control group (p < 0.01). In contrast, the family members of the POP group did not report a higher prevalence of collagen-associated disorders compared to the family members of the control group (p = 0.82).

Conclusions

POP and other collagen-associated disorders may have a common aetiology, originating at the molecular level of the collagens.

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Title: Pelvic organ prolapse and collagen-associated disorders
Authors: Karin Lammers
Sabrina L. Lince
Marian A. Spath
Léon C. L. T. van Kempen
Jan C. M. Hendriks
Mark E. Vierhout
Kirsten B. Kluivers
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 3/2012
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-011-1532-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Pelvic organ prolapse and collagen-associated disorders

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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