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International Urogynecology Journal

Published in:

01-09-2009 | Original Article

Does COLIA1 SP1-binding site polymorphism predispose women to pelvic organ prolapse?

Authors: Benjamin Feiner, Fuad Fares, Nail Azam, Ron Auslender, Miriam David, Yoram Abramov

Published in: International Urogynecology Journal | Issue 9/2009

Abstract

Introduction and hypothesis

COLIA1 polymorphism is associated with increased risk for stress urinary incontinence. We hypothesize that a similar association exists with pelvic organ prolapse (POP).

Methods

Patients with advanced prolapse and healthy controls were evaluated by interview, validated questionnaires, and pelvic examination. DNA was extracted from peripheral blood, and polymerase chain reaction was performed to determine the presence or absence of the polymorphism. Power calculation indicated the need for 36 patients in each arm.

Results

The prevalence of the polymorphic heterozygous genotype (GT) in the study and control groups was 33.3% and 19.4%, respectively, leading to an odds ratio of 1.75. This difference, however, did not reach statistical significance (p = 0.27).

Conclusions

The COLIA1 polymorphism was not significantly associated with increased risk for POP.

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Title: Does COLIA1 SP1-binding site polymorphism predispose women to pelvic organ prolapse?
Authors: Benjamin Feiner
Fuad Fares
Nail Azam
Ron Auslender
Miriam David
Yoram Abramov
Publication date: 01-09-2009
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 9/2009
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-009-0895-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Does COLIA1 SP1-binding site polymorphism predispose women to pelvic organ prolapse?

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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