Issue 1/2021
This issue contains themed sections on Alpha Particles Therapy and TSPO Imaging.
Content (40 Articles)
The false myth of “iodine allergy” also in nuclear medicine
Jesús Luis Gómez-Perales, Antonio García-Mendoza
From radiotracer to radiopharmaceutical: a philosophical approach
Stefano Boschi, Sergio Todde
Imaging and dosimetry for alpha-particle emitter radiopharmaceutical therapy: improving radiopharmaceutical therapy by looking into the black box
George Sgouros, Eric Frey, Yong Du, Rob Hobbs, Wesley Bolch
Global experience with PSMA-based alpha therapy in prostate cancer
Mike M. Sathekge, Frank Bruchertseifer, Mariza Vorster, Alfred Morgenstern, Ismaheel O. Lawal
Targeted α-therapy in non-prostate malignancies
Hossein Jadvar, Patrick M. Colletti
Dosing 225Ac-DOTATOC in patients with somatostatin-receptor-positive solid tumors: 5-year follow-up of hematological and renal toxicity
Clemens Kratochwil, Leonidas Apostolidis, Hendrik Rathke, Christos Apostolidis, Felix Bicu, Frank Bruchertseifer, Peter L Choyke, Uwe Haberkorn, Frederik L Giesel, Alfred Morgenstern
National Cancer Institute support for targeted alpha-emitter therapy
Julie A. Hong, Martin Brechbiel, Jeff Buchsbaum, Christie A. Canaria, C. Norman Coleman, Freddy E. Escorcia, Michael Espey, Charles Kunos, Frank Lin, Deepa Narayanan, Jacek Capala
Correction to: Global experience with PSMA‑based alpha therapy in prostate cancer
Mike M. Sathekge, Frank Bruchertseifer, Mariza Vorster, Alfred Morgenstern, Ismaheel O. Lawal
Imaging translocator protein expression with positron emission tomography
Catriona Wimberley, Irene Buvat, Hervé Boutin
TSPO imaging in animal models of brain diseases
Nadja Van Camp, Sonia Lavisse, Pauline Roost, Francesco Gubinelli, Ansel Hillmer, Hervé Boutin
Radiosynthesis and characterization of [18F]BS224: a next-generation TSPO PET ligand insensitive to the rs6971 polymorphism
Sang Hee Lee, Nunzio Denora, Valentino Laquintana, Giuseppe Felice Mangiatordi, Angela Lopedota, Antonio Lopalco, Annalisa Cutrignelli, Massimo Franco, Pietro Delre, In Ho Song, Hye Won Kim, Su Bin Kim, Hyun Soo Park, Kyungmin Kim, Seok-Yong Lee, Hyewon Youn, Byung Chul Lee, Sang Eun Kim
Preclinical evaluation of (S)-[18F]GE387, a novel 18-kDa translocator protein (TSPO) PET radioligand with low binding sensitivity to human polymorphism rs6971
Nisha K. Ramakrishnan, Matthew Hird, Stephen Thompson, David J. Williamson, Luxi Qiao, David R. Owen, Allen F. Brooks, Peter J. H. Scott, Sergio Bacallado, John T. O’Brien, Franklin I. Aigbirhio
Modelling [18F]LW223 PET data using simplified imaging protocols for quantification of TSPO expression in the rat heart and brain
Mark G. MacAskill, Catriona Wimberley, Timaeus E. F. Morgan, Carlos J. Alcaide-Corral, David E. Newby, Christophe Lucatelli, Andrew Sutherland, Sally L. Pimlott, Adriana A. S. Tavares
Cellular sources of TSPO expression in healthy and diseased brain
Erik Nutma, Kelly Ceyzériat, Sandra Amor, Stergios Tsartsalis, Philippe Millet, David R. Owen, Vassilios Papadopoulos, Benjamin B. Tournier
Applicability, potential and limitations of TSPO PET imaging as a clinical immunopsychiatry biomarker
Livia J. De Picker, Benno C. M. Haarman
Imaging of the glioma microenvironment by TSPO PET
Bastian Zinnhardt, Federico Roncaroli, Claudia Foray, Erjon Agushi, Bahiya Osrah, Gaëlle Hugon, Andreas H. Jacobs, Alexandra Winkeler
Contribution of TSPO imaging in the understanding of the state of gliosis in substance use disorders
Claire Leroy, Wadad Saba
Have (R)-[11C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies
Fabien Chauveau, Guillaume Becker, Hervé Boutin
What value can TSPO PET bring for epilepsy treatment?
Viviane Bouilleret, Stefanie Dedeurwaerdere
Reduced microglia activity in patients with long-term immunosuppressive therapy after liver transplantation
Meike Dirks, Ralph Buchert, Ann-Katrin Wirries, Henning Pflugrad, Gerrit M. Grosse, Carlotta Petrusch, Christian Schütze, Florian Wilke, Martin Mamach, Linda Hamann, Laura B. N. Langer, Xiao-Qi Ding, Hannelore Barg-Hock, Jürgen Klempnauer, Christian H. Wetzel, Mario Lukacevic, Eike Janssen, Mariella Kessler, Frank M. Bengel, Lilli Geworski, Rainer Rupprecht, Tobias L. Ross, Georg Berding, Karin Weissenborn
Kinetic modeling and parameter estimation of TSPO PET imaging in the human brain
Catriona Wimberley, Sonia Lavisse, Ansel Hillmer, Rainer Hinz, Federico Turkheimer, Paolo Zanotti-Fregonara
Supervised clustering for TSPO PET imaging
Julia Schubert, Matteo Tonietto, Federico Turkheimer, Paolo Zanotti-Fregonara, Mattia Veronese
Can the BMI-based dose regimen be used to reduce injection activity and to obtain a constant image quality in oncological patients by 18F-FDG total-body PET/CT imaging?
Jie Xiao, Haojun Yu, Xiuli Sui, Yan Hu, Yanyan Cao, Guobing Liu, Yiqiu Zhang, Pengcheng Hu, Ying Wang, Chenwei Li, Baixuan Xu, Hongcheng Shi
Cyclotron production of 225Ac from an electroplated 226Ra target
Kotaro Nagatsu, Hisashi Suzuki, Masami Fukada, Taku Ito, Jun Ichinose, Yoshio Honda, Katsuyuki Minegishi, Tatsuya Higashi, Ming-Rong Zhang
68Ga-FAPI-04 vs. 18F-FDG in a longitudinal preclinical PET imaging of metastatic breast cancer
Fan Ding, Chen Huang, Chenyi Liang, Cheng Wang, Jianjun Liu, Dewei Tang
Novel CYP11B-ligand [123/131I]IMAZA as promising theranostic tool for adrenocortical tumors: comprehensive preclinical characterization and first clinical experience
Britta Heinze, Andreas Schirbel, Lukas Nannen, David Michelmann, Philipp E. Hartrampf, Christina Bluemel, Magdalena Schneider, Ken Herrmann, Heribert Haenscheid, Martin Fassnacht, Andreas K. Buck, Stefanie Hahner
Prognostic value of regional myocardial flow reserve derived from 13N-ammonia positron emission tomography in patients with suspected coronary artery disease
Elia von Felten, Dominik C. Benz, Georgios Benetos, Jessica Baehler, Dimitri Patriki, Georgios P. Rampidis, Andreas A. Giannopoulos, Adam Bakula, Christoph Gräni, Aju P. Pazhenkottil, Catherine Gebhard, Tobias A. Fuchs, Philipp A. Kaufmann, Ronny R. Buechel
Harmonisation of PET imaging features with different amyloid ligands using machine learning-based classifier
Sung Hoon Kang, Jeonghun Kim, Jun Pyo Kim, Soo Hyun Cho, Yeong Sim Choe, Hyemin Jang, Hee Jin Kim, Seong-Beom Koh, Duk L. Na, Joon-Kyung Seong, Sang Won Seo
[18F]FDG PET/CT imaging disproves renal allograft acute rejection in kidney transplant recipients with acute kidney dysfunction: a validation cohort
P. Lovinfosse, L. Weekers, H. Pottel, A. Bouquegneau, C. Bonvoisin, C. Bovy, S. Grosch, R. Hustinx, Francois Jouret
Intra-articular use of radium dichloride ([223Ra] RaCl2) showed relevant anti-inflammatory response on experimental arthritis model
Luana Barbosa Corrêa, Maria das Graças Muller de Oliveira Henriques, Elaine Cruz Rosas, Ralph Santos-Oliveira
Current status and quality of radiomic studies for predicting immunotherapy response and outcome in patients with non-small cell lung cancer: a systematic review and meta-analysis
Qiuying Chen, Lu Zhang, Xiaokai Mo, Jingjing You, Luyan Chen, Jin Fang, Fei Wang, Zhe Jin, Bin Zhang, Shuixing Zhang
Role of a portable gamma-camera with optical view for margins assessment of pulmonary nodules resected by radioguided surgery
Ivan Vollmer, Nuria Sánchez-Izquierdo, Daniel Martínez, David Sánchez-Lorente, Sebastián Casanueva-Eliceiry, Marc Boada, Ángela Guirao, Inmaculada Romero-Zayas, Sergi Vidal-Sicart, Pilar Paredes
FDG-PET/CT in colorectal cancer: potential for vascular-metabolic imaging to provide markers of prognosis
Shih-hsin Chen, Kenneth Miles, Stuart A. Taylor, Balaji Ganeshan, Manuel Rodriquez, Francesco Fraioli, Simon Wan, Asim Afaq, Robert Shortman, Darren Walls, Luke Hoy, Raymond Endozo, Aman Bhargava, Matthew Hanson, Joseph Huang, Sherif Raouf, Daren Francis, Shahab Siddiqi, Tan Arulampalam, Bruce Sizer, Michael Machesney, Nicholas Reay-Jones, Sanjay Dindyal, Tony Ng, Ashley M Groves
High fibroblast-activation-protein expression in castration-resistant prostate cancer supports the use of FAPI-molecular theranostics
Claudia Kesch, Leubet Yirga, Katharina Dendl, Analena Handke, Christopher Darr, Ulrich Krafft, Jan Philipp Radtke, Stephan Tschirdewahn, Tibor Szarvas, Ladan Fazli, Martin Gleave, Frederik L. Giesel, Uwe Haberkorn, Boris Hadaschik
[18F]-Fluciclovine PET/CT for preoperative nodal staging in high-risk primary prostate cancer: final results of a prospective trial
Lucia Zanoni, Lorenzo Bianchi, Cristina Nanni, Cristian Pultrone, Francesca Giunchi, Irene Bossert, Antonella Matti, Riccardo Schiavina, Michelangelo Fiorentino, Daniele Romagnoli, Cristina Fonti, Filippo Lodi, Antonietta D’Errico, Eugenio Brunocilla, Angelo Porreca, Stefano Fanti
Positive [18F]fluoroethyltyrosine PET/MRI in suspected recurrence of growth hormone–producing pituitary adenoma in a paediatric patient
Sophie E. M. Veldhuijzen van Zanten, Sebastian J. C. M. M. Neggers, Roelf Valkema, Frederik A. Verburg
Accurate detection of intracranial extension of jugulotympanic paraganglioma by [18F]FDOPA-PET/CT comparing to MRI
Zahra Jamshidi Araghi, Shaghayegh Ranjbar, Michael Paar, Christian Pirich, Mohsen Beheshti
Increased [68 Ga]Ga-FAPI uptake in focal nodular hyperplasia in a patient with sigmoid colon cancer
Qihang Shang, Li Fu, Yizhen Pang, Tinghua Meng, Xiurong Wu, Long Sun, Haojun Chen
Imaging dysregulated calcium homeostasis in acute myocardial infarction with [68 Ga]Ga-NODAGAZOL
Honest Ndlovu, Ismaheel Lawal, Kgomotso Mokoala, Letjie C. Maserumule, Khanyisile N. Hlongwa, Johncy Mahapane, Bradley Brits, Tyronne Annor, Mariza Vorster, Mike Sathekge