Published in:
26-12-2023 | Esophagogastroduodenoscopy | Image of the Month
Sotos Syndrome with NSDI Gene Mutations and Li–Fraumeni Syndrome with TP53 Gene Mutations in a Patient with Multiple Gastric Signet-Ring Cell Carcinomas
Published in: Digestive Diseases and Sciences | Issue 2/2024
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A 43-year-old female underwent esophagogastroduodenoscopy for complaints of epigastric pain. Multiple intramucosal lesions in the antrum were visualized (Fig. 1), which were diagnosed as signet-ring cell carcinoma on the basis of histology and immunochemical staining (Fig. 2). Subsequent endoscopic submucosal dissection (ESD) was used to resect the gastric lesions and separately found colonic lesions.
Fig. 1
Lesions of the gastric body near the gastric angle under A white light and B narrow-band imaging. Images of the posterior wall of the gastric antrum under C white light and D narrow-band imaging
Fig. 2
Conventional pathology and immunohistochemistry. Histology of the gastric antrum (A) and body (B) showing evidence of adenocarcinoma. Positive immunohistochemical staining for MUC-6 (C), desmin (D), Ki-67 (E), and MUC-5ac (F)
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