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Neurology Epilepsy

Epilepsy

Triple pathology in uncontrolled epilepsy

Changes in seizure semiology and MRI findings indicated the unusual coexistence of low-grade glioma and hippocampal sclerosis in a 29-year-old patient with Sturge–Weber syndrome.

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Editor's Choice

Treating seizures in oncology patients

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What’s best practice for managing seizures in patients with primary brain tumors or brain metastases, or as a consequence of cancer therapy?

Fenfluramine in developmental and epileptic encephalopathies

Expert practical recommendations on using fenfluramine, which is the latest therapeutic option for seizure management in Dravet syndrome and Lennox–Gastaut syndrome.

AI model improves focal cortical dysplasia diagnosis

An artificial intelligence model using MRI data could help identify focal cortical dysplasia, outperforming existing diagnostic models.

CV effects of antiseizure medications for epilepsy

Antiseizure medications can adversely affect lipid profiles and cause cardiac arrhythmias, increasing cardiovascular morbidity and mortality. How can you identify patients at risk and when to intervene?

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Keynote webinar | Spotlight on sleep in brain health

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.

Dr. Rolf Fronczek
Dr. Renata Riha
Dr. Sven Rupprecht
Developed by: Springer Medicine
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Video

Case Studies

Triple pathology in uncontrolled epilepsy

Changes in seizure semiology and MRI findings indicated the unusual coexistence of low-grade glioma and hippocampal sclerosis in a 29-year-old patient with Sturge–Weber syndrome.

Is abdominal pain signaling acute intermittent porphyria?

AIP can easily be overlooked in its early stages. When a patient presents with central, peripheral, or autonomic nervous system symptoms and common causes are ruled out, AIP should be considered.

Lead encephalopathy from chipped paint

Public health measures mean severe lead toxicity is rare, making its recognition and management challenging. This 4-year-old presented with refractory status epilepticus and severe microcytic anemia. How would you diagnose and treat her?

Episode 4: Stem cell therapy for PD

A new era for managing Parkinson’s disease?

STEM-PD, the first in-human safety trial of stem cell therapy for Parkinson’s disease, began this year and marks a huge step forward for this type of treatment.

We talk to Prof. Malin Parmar about why stem cell therapy is such a good option for patients with Parkinson’s disease and get an update on the current status of the trial.

Dr. Malin Parmar
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Podcast

Current Reviews

Advances in Neonatal Seizures (2024): An Update for Pediatricians

Seizures are more common in the neonatal period than any other time due to the greater propensity of the immature brain to develop seizures, making them the most common neurological emergency in the neonatal period. The unique attribute of …

Neurostimulation in Childhood Epilepsy

Epilepsy is a common and debilitating neurological disorder in children, and approximately a third of them have ongoing seizures despite adequate trial of antiseizure medications. Neurostimulation approaches may be an option for those with drug …

The prevalence of post-therapy epilepsy in patients treated for high-grade glial tumors: a systematic review and meta-analysis

Gliomas are the most prevalent type of primary brain tumor of the adult central nervous system. High-grade gliomas (HGG) are the most common type of glioma. Epilepsy is often the first clinical manifestation of HGG. Since epilepsy leads to …

Mortality in patients with epilepsy: a systematic review

Epilepsy is a chronic neurological disorder that affects over 65 million people globally, characterized by recurrent seizures [ 1 ]. According to the GBD study, approximately 140,000 individuals with idiopathic epilepsy died worldwide in 2021. A …

Further Reading

Cenobamate as add-on treatment in ultra-refractory focal epilepsy: Real-world results from The Danish Epilepsy Centre, Dianalund, Denmark

In the treatment of epilepsy, seizure remission without intolerable or harmful adverse events is the ultimate goal. However, 30–40% of patients with epilepsy do not achieve adequate seizure control despite the availability of a large selection of …

Neurostimulation in Childhood Epilepsy

Epilepsy is a common and debilitating neurological disorder in children, and approximately a third of them have ongoing seizures despite adequate trial of antiseizure medications. Neurostimulation approaches may be an option for those with drug …

The statistical impact of ROI referencing on quantitative susceptibility mapping

In quantitative susceptibility mapping (QSM), it is impossible to define an absolute reference for the reconstructed susceptibility values. Therefore, it has been suggested to use a relative reference, such as the mean susceptibility within an …

Does deep brain stimulation of the anterior nucleus of the thalamus represent the future of Lennox–Gastaut syndrome?

Lennox–Gastaut Syndrome (LGS) is a severe form of epilepsy that usually begins before 8 years of age. Onset after 10 years of age is rare. In some cases, it follows a generalized or focal epilepsy or occurs under particular conditions, such as …