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European Radiology
Published in: European Radiology 8/2017

01-08-2017 | Cardiac

Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging

Authors: Akos Varga-Szemes, Rob J. van der Geest, U. Joseph Schoepf, Bruce S. Spottiswoode, Carlo N. De Cecco, Giuseppe Muscogiuri, Julian L. Wichmann, Stefanie Mangold, Stephen R. Fuller, Pal Maurovich-Horvat, Bela Merkely, Sheldon E. Litwin, Rozemarijn Vliegenthart, Pal Suranyi

Published in: European Radiology | Issue 8/2017

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Abstract

Objectives

To evaluate the influence of inversion time (TI) on the precision of myocardial late gadolinium enhancement (LGE) quantification using synthetic inversion recovery (IR) imaging in patients with myocardial infarction (MI).

Methods

Fifty-three patients with suspected prior MI underwent 1.5-T cardiac MRI with conventional magnitude (MagIR) and phase-sensitive IR (PSIR) LGE imaging and T1 mapping at 15 min post-contrast. T1-based synthetic MagIR and PSIR images were calculated with a TI ranging from −100 to +150 ms at 5-ms intervals relative to the optimal TI (TI0). LGE was quantified using a five standard deviation (5SD) and full width at half-maximum (FWHM) thresholds. Measurements were compared using one-way analysis of variance.

Results

The MagIRsy technique provided precise assessment of LGE area at TIs ≥ TI0, while precision was decreased below TI0. The LGE area showed significant differences at ≤ −25 ms compared to TI0 using 5SD (P < 0.001) and at ≤ −65 ms using the FWHM approach (P < 0.001). LGE measurements did not show significant difference over the analysed TI range in the PSIRsy images using either of the quantification methods.

Conclusions

T1 map-based PSIRsy images provide precise quantification of MI independent of TI at the investigated time point post-contrast. MagIRsy-based MI quantification is precise at TI0 and at longer TIs while showing decreased precision at TI values below TI0.

Key Points

• Synthetic IR imaging retrospectively generates LGE images at any theoretical TI
• Synthetic IR imaging can simulate the effect of TI on LGE quantification
• Fifteen minutes post-contrast MagIR sy accurately quantifies infarcts from TI 0 to TI 0   + 150 ms
• Fifteen minutes post-contrast PSIR sy provides precise infarct size independent of TI
• Synthetic IR imaging has further advantages in reducing operator dependence
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Metadata
Title
Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imaging
Authors
Akos Varga-Szemes
Rob J. van der Geest
U. Joseph Schoepf
Bruce S. Spottiswoode
Carlo N. De Cecco
Giuseppe Muscogiuri
Julian L. Wichmann
Stefanie Mangold
Stephen R. Fuller
Pal Maurovich-Horvat
Bela Merkely
Sheldon E. Litwin
Rozemarijn Vliegenthart
Pal Suranyi
Publication date
01-08-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 8/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4665-z

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