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European Radiology
Published in: European Radiology 8/2017

01-08-2017 | Experimental

Everyman’s prostate phantom: kiwi-fruit substitute for human prostates at magnetic resonance imaging, diffusion-weighted imaging and magnetic resonance spectroscopy

Authors: Ullrich G. Mueller-Lisse, Sophie Murer, Ulrike L. Mueller-Lisse, Marissa Kuhn, Juergen Scheidler, Michael Scherr

Published in: European Radiology | Issue 8/2017

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Abstract

Objectives

To apply an easy-to-assemble phantom substitute for human prostates in T2-weighted magnetic resonance imaging (T2WI), diffusion-weighted imaging (DWI) and 3D magnetic resonance spectroscopy (MRS).

Methods

Kiwi fruit were fixed with gel hot and cold compress packs on two plastic nursery pots, separated by a plastic plate, and submerged in tap water inside a 1-L open-spout plastic watering can for T2WI (TR/TE 7500/101 ms), DWI (5500/61 ms, ADC b50–800 s/mm2 map) and MRS (940/145 ms) at 3.0 T, with phased array surface coils. One green kiwi fruit was additionally examined with an endorectal coil. Retrospective comparison with benign peripheral zone (PZ) and transitional zone (TZ) of prostate (n = 5), Gleason 6–7a prostate cancer (n = 8) and Gleason 7b–9 prostate cancer (n = 7) validated the phantom.

Results

Mean contrast between central placenta (CP) and outer pericarp (OP, 0.346–0.349) or peripheral placenta (PP, 0.364–0.393) of kiwi fruit was similar to Gleason 7b–9 prostate cancer and PZ (0.308) in T2WI. ADC values of OP and PP (1.27 ± 0.07–1.37 ± 0.08 mm2/s × 10−3) resembled PZ and TZ (1.39 ± 0.17–1.60 ± 0.24 mm2/s × 10−3), while CP (0.91 ± 0.14–0.99 ± 0.10 mm2/s × 10−3) resembled Gleason 7b–9 prostate cancer (1.00 ± 0.25 mm2/s × 10−3). MR spectra showed peaks of citrate and myo-inositol in kiwi fruit, and citrate and “choline+creatine” in prostates. The phantom worked with an endorectal coil, too.

Conclusions

The kiwi fruit phantom reproducibly showed zones similar to PZ, TZ and cancer in human prostates in T2WI and DWI and two metabolite peaks in MRS and appears suitable to compare different MR protocols, coil systems and scanners.

Key Points

• Kiwi fruit appear suitable as phantoms for human prostate in MR examinations.
• Kiwi fruit show zonal anatomy like human prostates in T2-weighted MRI and DWI.
• MR spectroscopy reliably shows peaks in kiwi fruit (citrate/inositol) and human prostates (citrate/choline+creatine).
• The kiwi fruit phantom works both with and without an endorectal coil.
• EU regulation No. 543/2011 specifies physical and biochemical properties of kiwi fruit.
Literature
1.
De Visschere PJ, Vral A, Perletti G et al (2016) Multiparametric magnetic resonance imaging characteristics of normal, benign and malignant conditions in the prostate. Eur Radiol. doi:10.​1007/​s00330-016-4479-z
2.
3.
Roethke M, Blondin D, Schlemmer HP, Franiel T (2013) PI-RADS classification: structured reporting for MRI of the prostate. Fortschr Röntgenstr 185:253–261CrossRef
4.
Abd-Alazeez M, Ahmed HU, Arya M et al (2014) The accuracy of multiparametric MRI in men with negative biopsy and elevated PSA level—can it rule out clinically significant prostate cancer? Urol Oncol 32:45.e17–22CrossRef
5.
Wefer AE, Hricak H, Vigneron DB et al (2000) Sextant localization of prostate cancer: comparison of sextant biopsy, magnetic resonance imaging and magnetic resonance spectroscopic imaging with step section histology. J Urol 164:400–404CrossRefPubMed
6.
Labanaris AP, Engelhard K, Zugor V, Nützel R, Kühn R (2010) Prostate cancer detection using an extended prostate biopsy schema in combination with additional targeted cores from suspicious images in conventional and functional endorectal magnetic resonance imaging of the prostate. Prostate Cancer Prostatic Dis 13:65–70CrossRefPubMed
7.
Sciarra A, Panebianco V, Ciccariello M et al (2010) Value of magnetic resonance spectroscopy imaging and dynamic contrast-enhanced imaging for detecting prostate cancer foci in men with prior negative biopsy. Clin Cancer Res 16:1875–1883CrossRefPubMed
8.
Umbehr M, Bachmann LM, Held U et al (2009) Combined magnetic resonance imaging and magnetic resonance spectroscopy imaging in the diagnosis of prostate cancer: a systematic review and meta-analysis. Eur Urol 55:575–590CrossRefPubMed
9.
Schoots IG, Petrides N, Giganti F et al (2015) Magnetic resonance imaging in active surveillance of prostate cancer: a systematic review. Eur Urol 67:627–636CrossRefPubMed
10.
Weinreb JC, Barentsz JO, Choyke PL et al (2016) PI-RADS Prostate Imaging - Reporting and Data System: 2015, Version 2. Eur Urol 69:16–40CrossRefPubMed
11.
12.
de Rooij M, Hamoen EH, Fütterer JJ, Barentsz JO, Rovers MM (2014) Accuracy of multiparametric MRI for prostate cancer detection: a meta-analysis. AJR Am J Roentgenol 202:343–351CrossRefPubMed
13.
Kuru TH, Roethke M, Popeneciu V et al (2012) Phantom study of a novel stereotactic prostate biopsy system integrating preinterventional magnetic resonance imaging and live ultrasonography fusion. J Endourol 26:807–813CrossRefPubMed
14.
15.
Kurhanewicz J, Vigneron DB, Hricak H et al (1996) Three-dimensional H-1 MR spectroscopic imaging of the in situ human prostate with high (0.24–0.7cm3) spatial resolution. Radiology 198:795–805CrossRefPubMed
16.
17.
Pfeuffer J, Tkac I, Provencher SW, Gruetter R (1999) Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time 1H NMR spectra of the rat brain. J Magn Reson 141:104–120CrossRefPubMed
18.
19.
Latocha P, Olszewska-Kaczynska I (2003) Preliminary, morphological, chemical and sensory analysis of fruit of different Actinidia genotypes (Actinidia Lindl.). Ann Warsaw Agric Univ – SGGW Horticulture and Landscape Architecture 24:51-56
20.
Nardozza S (2007) Genotypic variation in Actinidia deliciosa fruit size and carbohydrate content. Alma Mater Studiorum Università Degli Studi Di Bologna, Facoltà Di Agraria, Dipartimento di Colture Arboree, Dottorato di Ricerca in Colture Arboree ed Agrosistemi Forestali Ornamentali e Paesaggistici – AGR/03, Anno Accademico 2006/2007
21.
European Commission (2011) Commission Implementing Regulation (EU) No 543/2011 of 7 June 2011, laying down detailed rules for the application of council regulation (EC) No 1234/2007 in respect of the fruit and vegetables and processed fruit and vegetables sectors. Off J Eur Union 15.06.2011, L157/1-163
22.
Mueller-Lisse U, Mueller-Lisse U, Scheidler J, Klein G, Reiser M (2005) Reproducibility of image interpretation in MRI of the prostate: application of the sextant framework by two different radiologists. Eur Radiol 15:1826–1833CrossRefPubMed
23.
Glantz SA (2012) The special case of two groups: the t test. In: Glantz SA (ed) Primer of biostatistics, 7th edn, Chap 4. McGraw-Hill Medical, New York, pp 49–72
24.
Klages K, Donnison H, Boldingh H, MacRae E (1998) myo-Inositol is the major sugar in Actinidia arguta during early fruit development. Aust J Plant Physiol 25:61–67CrossRef
25.
26.
Weis J, Ortiz-Nieto F, Ahlström H (2013) MR spectroscopy of the prostate at 3T: measurements of relaxation times and quantification of prostate metabolites using water as an internal reference. Magn Reson Med Sci 12:289–296CrossRefPubMed
27.
Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hänicke W, Sauter R (1989) Localized proton NMR spectroscopy in different regions of the human brain in vivo. Relaxation times and concentrations of cerebral metabolites. Magn Reson Med 11:47–63CrossRefPubMed
28.
Terpstra M, Gruetter R (2004) 1H NMR detection of vitamin C in human brain in vivo. Magn Reson Med 51:225–229CrossRefPubMed
29.
Jafar MM, Parsai A, Miquel ME (2016) Diffusion-weighted magnetic resonance imaging in cancer: Reported apparent diffusion coefficients, in-vitro and in-vivo reproducibility. World J Radiol 8:21–49CrossRefPubMedPubMedCentral
30.
Mueller-Lisse UG, Mueller-Lisse UL, Zamecnik P, Schlemmer HP, Scherr MK (2011) Diffusion-weighted MRI of the prostate. Radiologe 51:205–214CrossRefPubMed
31.
Yağcı AB, Özarı N, Aybek Z, Düzcan E (2011) The value of diffusion-weighted MRI for prostate cancer detection and localization. Diagn Interv Radiol 17:130–134PubMed
32.
Boesen L, Chabanova E, Løgager V, Balslev I, Thomsen HS (2015) Apparent diffusion coefficient ratio correlates significantly with prostate cancer Gleason score at final pathology. J Magn Reson Imaging 42:446–453CrossRefPubMed
33.
Mikulic-Petkovsek M, Schmitzer V, Slatnar A et al (2012) Composition of sugars, organic acids, and total phenolics in 25 wild or cultivated berry species. J Food Sci 77:C1064–C1070CrossRefPubMed
34.
Metadata
Title
Everyman’s prostate phantom: kiwi-fruit substitute for human prostates at magnetic resonance imaging, diffusion-weighted imaging and magnetic resonance spectroscopy
Authors
Ullrich G. Mueller-Lisse
Sophie Murer
Ulrike L. Mueller-Lisse
Marissa Kuhn
Juergen Scheidler
Michael Scherr
Publication date
01-08-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 8/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4706-7

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