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Published in: Cancer and Metastasis Reviews 4/2017

01-12-2017

E3 ubiquitin ligases in cancer and implications for therapies

Authors: Dong Wang, Leina Ma, Bin Wang, Jia Liu, Wenyi Wei

Published in: Cancer and Metastasis Reviews | Issue 4/2017

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Abstract

E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their degradation, which are of importance in cellular homeostasis. Since many oncogenic or tumor-suppressive proteins are reported to be regulated by the ubiquitin-proteasome system (UPS), E3 ligases, which function as substrate interacting modules, have been attracting more and more attention as promising anticancer drug targets due to their pivotal role in conferring substrate specificity. Generally, based on their molecular structure and functional mechanism, E3 ligases can be divided into three major types: homologous to E6-associated protein C-terminus (HECT), really interesting new gene (RING), and RING-in-between-RING (RBR) E3 ligases. Based on the significance of their functions, more bioactive compounds targeting E3 ligases should be developed in the future. In this review, we discuss the important roles of E3 ligases involved in cancer as well as available bioactive compounds targeting various E3 ligases for potential anticancer activity.
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Metadata
Title
E3 ubiquitin ligases in cancer and implications for therapies
Authors
Dong Wang
Leina Ma
Bin Wang
Jia Liu
Wenyi Wei
Publication date
01-12-2017
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 4/2017
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-017-9703-z

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