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European Radiology

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01-08-2014 | Computed Tomography

Dual-energy computed tomography for the assessment of early treatment effects of regorafenib in a preclinical tumor model: comparison with dynamic contrast-enhanced CT and conventional contrast-enhanced single-energy CT

Authors: Gesine Knobloch, Gregor Jost, Alexander Huppertz, Bernd Hamm, Hubertus Pietsch

Published in: European Radiology | Issue 8/2014

Abstract

Objectives

The potential diagnostic value of dual-energy computed tomography (DE-CT) compared to dynamic contrast-enhanced CT (DCE-CT) and conventional contrast-enhanced CT (CE-CT) in the assessment of early regorafenib treatment effects was evaluated in a preclinical setting.

Methods

A rat GS9L glioma model was examined with contrast-enhanced dynamic DE-CT measurements (80 kV/140 kV) for 4 min before and on days 1 and 4 after the start of daily regorafenib or placebo treatment. Tumour time-density curves (0-240 s, 80 kV), DE-CT (60 s) derived iodine maps and the DCE-CT (0-30 s, 80 kV) based parameters blood flow (BF), blood volume (BV) and permeability (PMB) were calculated and compared to conventional CE-CT (60 s, 80 kV).

Results

The regorafenib group showed a marked decrease in the tumour time-density curve, a significantly lower iodine concentration and a significantly lower PMB on day 1 and 4 compared to baseline, which was not observed for the placebo group. CE-CT showed a significant decrease in tumour density on day 4 but not on day 1. The DE-CT-derived iodine concentrations correlated with PMB and BV but not with BF.

Conclusions

DE-CT allows early treatment monitoring, which correlates with DCE-CT. Superior performance was observed compared to single-energy CE-CT.

Key Points

• Regorafenib treatment response was evaluated by CT in a rat tumour model.

• Dual-energy contrast-enhanced CT allows early treatment monitoring of targeted anti-tumour therapies.

• Dual-energy CT showed higher diagnostic potential than conventional contrast enhanced single-energy CT.

• Dual-energy CT showed diagnostic potential comparable to dynamic contrast-enhanced CT.

• Dual-energy CT is a promising method for efficient clinical treatment response evaluation.

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Title: Dual-energy computed tomography for the assessment of early treatment effects of regorafenib in a preclinical tumor model: comparison with dynamic contrast-enhanced CT and conventional contrast-enhanced single-energy CT
Authors: Gesine Knobloch
Gregor Jost
Alexander Huppertz
Bernd Hamm
Hubertus Pietsch
Publication date: 01-08-2014
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 8/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3193-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Dual-energy computed tomography for the assessment of early treatment effects of regorafenib in a preclinical tumor model: comparison with dynamic contrast-enhanced CT and conventional contrast-enhanced single-energy CT

Abstract

Objectives

Methods

Results

Conclusions

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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