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Diabetology Diabetic Emergency

Diabetic Emergency

Metformin beneficial when given after antenatal betamethasone

Metformin improves maternal glucose levels and lowers neonatal hypoglycemia risk versus standard care in women given antenatal betamethasone due to preterm delivery risk.

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Editor's Choice

Improving medication adherence in type 2 diabetes

Medication non-adherence remains a significant challenge in the management of type 2 diabetes. How should it be assessed, what are the consequences, and what are the interventions designed to improve adherence?

CGM benefits older adults with diabetes and dementia

Continuous glucose monitoring reduces the risk for hospitalization and mortality versus self-monitoring in insulin-treated older adults with diabetes and dementia.

Post-bariatric hypoglycemia in a patient with heart failure

A man who achieved diabetes remission after gastric bypass presented with hypoglycemic episodes and endogenous hyperinsulinemia. Hypoglycemia resolved and fasting tests normalized when sacubitril/valsartan was discontinued due to worsening renal function.

Meeting the challenge of glucose management in type 2 diabetes

Studies indicate that continuous glucose monitoring can improve morbidity and mortality in people with type 2 diabetes. This expert opinion considers the evidence base and makes the case for wider and earlier access.

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At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.

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Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care
Prof. Chantal Mathieu
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Case Studies

Post-bariatric hypoglycemia in a patient with heart failure

A man who achieved diabetes remission after gastric bypass presented with hypoglycemic episodes and endogenous hyperinsulinemia. Hypoglycemia resolved and fasting tests normalized when sacubitril/valsartan was discontinued due to worsening renal function.

Ketoacidosis in a man with type 1 diabetes treated with tirzepatide

Vigilance is key in people with type 1 diabetes who take tirzepatide. In this patient, ketoacidosis developed after malaise, aphagia, and malnutrition decreased his insulin requirements and he couldn’t manage his pump and sensor.

Non-islet cell tumor hypoglycemia and sarcoma

NICTH was diagnosed in a man with pelvic sarcoma. Severe hypoglycemia did not respond to standard treatments but had a partial response to rhGH and angioembolization of the tumor.

Keynote webinar | Spotlight on diet and diabetes

  • On-demand Webinar

An expert-led symposium exploring the prevention and management of type 2 diabetes through dietary interventions. Highlights include discussion of the recent EASD guidelines, therapeutic diets, food types and processing, plus psychological factors that influence patient success, and the drivers of healthy eating and diabetes control.

Prof. Mike Lean
Prof. Falko Sniehotta
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Current Reviews

Fully closed-loop systems: can people with type 1 diabetes just do it? Insights from open-source systems

Automated insulin delivery (AID) systems have significantly advanced diabetes management, progressively reducing user interactions required for optimal glucose management. This review evaluates the current landscape and future potential of AID …

Reference ranges of blood glucose values in healthy term neonates in their first days of life: a systematic review and meta-analysis 

Neonatal hypoglycaemia is the most common metabolic disorder in the first days of life. Pathological hypoglycaemia, characterized by persistent or recurrent low glucose levels, can lead to brain injury, resulting in long-term adverse …

Effects of insulin regimens for type 2 diabetes mellitus: a systematic review and network meta-analysis

Insulin therapy becomes necessary for many individuals with type 2 diabetes mellitus as pancreatic beta cell function progressively declines [ 1 ]. It is particularly indicated for those presenting with marked or symptomatic hyperglycaemia [ 2 ].

Use of Fixed Ratio Combinations to Improve Glycemic Control in Individuals with Type 2 Diabetes: Experts’ Opinion from the Gulf Region

Sequential addition of oral glucose-lowering therapies, insulin or incretin-based therapy is often required to attain optimal glycemic control and reduce the risk of diabetes-associated complications. Despite advances in treatment, a large …

Further Reading

Use of transoral outlet reduction endoscopy (TORE) in the management of resistant dumping syndrome

Luton and Dunstable Hospital (Bedfordshire Hospitals NHS Foundation Trust) is a high-volume tertiary referral bariatric unit in the UK providing obesity care services encompassing a population of 11 million. We maintain a database of all patients …

Analysis of glycaemic control and treatment satisfaction with a connected smart pen cap in adults with type 1 diabetes: a randomised, open-label, parallel-group trial

Sustained glycaemic management has been the cornerstone of type 1 diabetes management ever since pivotal trials demonstrated significant reductions in complications through use of intensive glucose targets [ 1 ]. However, achieving and maintaining …

Adrenaline is a prominent driver of inflammatory responses following hypoglycaemia

Type 1 diabetes is characterised by absolute insulin deficiency due to beta cell destruction in the pancreas. This insulin deficiency requires daily insulin administration to regulate glucose levels and prevent micro- and macrovascular …

Evaluation of Overall Health State, Treatment Burden, and Satisfaction with Insulin Efsitora Alfa (Efsitora) vs. Daily Comparator in Adults with Type 2 Diabetes in the QWINT Clinical Trial Program

  • Open Access
  • Insulins
  • Original Research

Type 2 diabetes (T2D) is a chronic condition characterized by insulin resistance and progressive beta-cell dysfunction, leading to hyperglycemia [ 1 ]. Despite guidelines advocating for treatment intensification as T2D progresses, there are often …

Image Credits
Premature baby with feeding tube/© Sergey Novikov / Stock.adobe.com (symbolic image with model), Diabetes kit/© ArtComma / iStock / Getty Images Plus, Older woman wearing a continuous glucose monitoring device/© Halfpoint / stock.adobe.com (symbolic image with model), Man taking a pill/© sebra / stock.adobe.com (symbolic image with model), Glucose monitor on upper arm/© Oksana Iermolinska / iStock / Getty Images Plus (symbolic image with model), Arrow on winding road/© Thiyanga / Generated with AI / Stock.adobe.com, Pregnant woman at a medical appointment/© Phushutter / stock.adobe.com (symbolic image with models), Close-up of a continuous glucose monitor on a child's arm/© (M) habrovich / stock.adobe.com (symbolic image with model), Woman monitoring glucose level with sensor and an app on her phone while training at swimming pool/© (M) Goffkein, stock.adobe.com (symbolic image with model), Man lying on a sofa/© urbazon / E+ / Getty Images (symbolic image with model), A large enhancing tumor in the pelvic cavity before and after embolization/© (M) 2025, Atefeh Jannatalipour et al, BMC Endocr Disord, Ketogenic diet concept/© a_namenko / Getty Images / iStock, 3D rendered risk index concept image/© Wong Yu Liang / Moment / Getty Images