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01-12-2019 | Paediatric Neuroradiology

Detection of occult abnormalities in the deep gray matter nuclei of neonates with punctate white matter lesions by magnetic resonance spectroscopy

Authors: Qinli Sun, Miaomiao Wang, Xianjun Li, Chao Jin, Hui Zhang, Yuli Zhang, Fan Wu, Zhe Liu, Xiaoyu Wang, Congcong Liu, Xiaocheng Wei, Duan Xu, Jian Yang

Published in: Neuroradiology | Issue 12/2019

Abstract

Purpose

Punctate white matter lesions (PWML) are common in preterm neonates and have also been reported in the full term. While most studies focus on white matter abnormalities, gray matter (GM) alterations are generally ignored due to the lack of abnormalities on conventional MRI. This study aims to investigate whether magnetic resonance spectroscopy is a sensitive and practical method to detect occult alterations of deep GM nuclei in these neonates.

Methods

Neonates with PWML and controls with no MRI abnormalities were retrospectively studied. Apparent diffusion coefficient values and metabolic ratios (Cho/Cr, NAA/Cho, and NAA/Cr) in the lenticular nucleus and the thalamus were compared between the PWML and control groups.

Results

Forty-two neonates with PWML (grades I, II, and III contained 14, 21, and 7 subjects, respectively) and 50 controls were enrolled. Apparent diffusion coefficient values in the lenticular nucleus and the thalamus were not significantly different between the PWML and the control groups. The NAA/Cho ratio was significantly lower in the PWML group than in the control group in both regions, whereas a lower NAA/Cr ratio was only observed in the thalamus. Significantly lower ratios of NAA/Cho in both regions and NAA/Cr in the thalamus were detected in the grade II and III subgroup, whereas the thalamic NAA/Cho ratio was decreased in the grade I group compared with controls.

Conclusions

Magnetic resonance spectroscopy is a sensitive method for detecting the occult deep GM abnormalities for the study cohort of neonates with PWML when compared with subjects without PWML.

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Title: Detection of occult abnormalities in the deep gray matter nuclei of neonates with punctate white matter lesions by magnetic resonance spectroscopy
Authors: Qinli Sun
Miaomiao Wang
Xianjun Li
Chao Jin
Hui Zhang
Yuli Zhang
Fan Wu
Zhe Liu
Xiaoyu Wang
Congcong Liu
Xiaocheng Wei
Duan Xu
Jian Yang
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 12/2019
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-019-02291-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Detection of occult abnormalities in the deep gray matter nuclei of neonates with punctate white matter lesions by magnetic resonance spectroscopy

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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