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Neuroradiology
Published in: Neuroradiology 12/2019

Open Access 01-12-2019 | Computed Tomography | Interventional Neuroradiology

Diagnostic accuracy of flat-panel computed tomography in assessing cerebral perfusion in comparison with perfusion computed tomography and perfusion magnetic resonance: a systematic review

Authors: Ernst L. Stille, Ilaria Viozzi, Mark ter Laan, Frederick J.A. Meijer, Jurgen J. Futterer, Maroeska M. Rovers

Published in: Neuroradiology | Issue 12/2019

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Abstract

Purpose

Flat-panel computed tomography (FP-CT) is increasingly available in angiographic rooms and hybrid OR’s. Considering its easy access, cerebral imaging using FP-CT is an appealing modality for intra-procedural applications. The purpose of this systematic review is to assess the diagnostic accuracy of FP-CT compared with perfusion computed tomography (CTP) and perfusion magnetic resonance (MRP) in cerebral perfusion imaging.

Methods

We performed a systematic literature search in the Cochrane Library, MEDLINE, Embase, and Web of Science up to June 2019 for studies directly comparing FP-CT with either CTP or MRP in vivo. Methodological quality was assessed using the QUADAS-2 tool. Data on diagnostic accuracy was extracted and pooled if possible.

Results

We found 11 studies comparing FP-CT with CTP and 5 studies comparing FP-CT with MRP. Most articles were pilot or feasibility studies, focusing on scanning and contrast protocols. All patients studied showed signs of cerebrovascular disease. Half of the studies were animal trials. Quality assessment showed unclear to high risks of bias and low concerns regarding applicability. Five studies reported on diagnostic accuracy; FP-CT shows good sensitivity (range 0.84–1.00) and moderate specificity (range 0.63–0.88) in detecting cerebral blood volume (CBV) lesions.

Conclusions

Even though FP-CT provides similar CBV values and reconstructed blood volume maps as CTP in cerebrovascular disease, additional studies are required in order to reliably compare its diagnostic accuracy with cerebral perfusion imaging.
Appendix
Available only for authorised users
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Metadata
Title
Diagnostic accuracy of flat-panel computed tomography in assessing cerebral perfusion in comparison with perfusion computed tomography and perfusion magnetic resonance: a systematic review
Authors
Ernst L. Stille
Ilaria Viozzi
Mark ter Laan
Frederick J.A. Meijer
Jurgen J. Futterer
Maroeska M. Rovers
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Published in
Neuroradiology / Issue 12/2019
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-019-02285-y

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