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Journal of Neurology

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20-11-2023 | Dementia | Original Communication

Dietary inflammatory index, genetic susceptibility and risk of incident dementia: a prospective cohort study from UK biobank

Authors: Min Peng, Shiqi Yuan, Dan Lu, Yitong Ling, Xiaxuan Huang, Jun Lyu, Anding Xu

Published in: Journal of Neurology | Issue 3/2024

Abstract

Background

Genetic factors, diet and inflammation are associated with the development of dementia. In this study, we aimed at evaluating the impact of the dietary inflammatory index (DII) scores and genetic susceptibility on the development of dementia.

Methods

This prospective study involved 207,301 participants aged between 39 and 72 years from UK biobank. A web-based 24-h dietary questionnaire was collected at least once from participants between 2006 and 2012. The DII was calculated based on inflammatory effect score of nutrients. Individual AD-GRS (Alzheimer’s disease genetic risk score) was calculated. Incident dementia was ascertained through hospital or death records.

Results

Of all 207,301 participants, 468 incident cases of all-cause dementia (165 AD, 91 VD and 26 FTD) were reported during a follow-up period of 11.4 years. The participants in the highest quintile (Q) of DII scores reported a higher risk for all-cause dementia (Q5 vs. Q3, hazard ratio (HR) = 1.702; 95% CI: 1.285–2.255) and VD (Q5 vs. Q3, HR = 2.266, 95% CI: 1.133–4.531) compared to participants in the Q3. Besides, when compared with the Q1, there was a higher risk for AD in the subjects of Q5 (Q5 vs. Q1, HR = 1.590; 95% CI: 1.004–2.519). There was a non-linear relationship between DII score and all-cause incidence (P for non-linear = 0.038) by restricted cubic splines. Subgroup analysis found that the increased risk for all-cause dementia and AD was more pronounced in the elderly, women, and higher educated population. Cox regression models indicated that compared with the participants who had a low AD-GRS risk and in the lowest tertile of DII, participants had a high AD-GRS and the highest tertile of DII were associated with a higher risk of AD (HR = 1.757, 95% CI: 1.082–2.855, P = 0.023).

Conclusions

The DII scores were independently associated with an augmented risk for all-cause dementia, AD and VD. Additionally, high AD-GRS with higher DII scores was significantly associated with a higher risk of AD.

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Title: Dietary inflammatory index, genetic susceptibility and risk of incident dementia: a prospective cohort study from UK biobank
Authors: Min Peng
Shiqi Yuan
Dan Lu
Yitong Ling
Xiaxuan Huang
Jun Lyu
Anding Xu
Publication date: 20-11-2023
Publisher: Springer Berlin Heidelberg
Keywords: Dementia
Dementia
Alzheimer's Disease
Alzheimer's Disease
Vascular Dementia
Vascular Dementia
Frontotemporal Dementia
Frontotemporal Dementia
Published in: Journal of Neurology / Issue 3/2024
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-023-12065-7

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Dietary inflammatory index, genetic susceptibility and risk of incident dementia: a prospective cohort study from UK biobank

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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