Skip to main content
Top
Published in: BMC Geriatrics 1/2024

Open Access 01-12-2024 | Dementia | Research

Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme

Authors: Serena Sabatini, Anthony Martyr, Anna Hunt, Laura D. Gamble, Fiona E. Matthews, Jeanette M. Thom, Roy W. Jones, Louise Allan, Martin Knapp, Christina Victor, Claire Pentecost, Jennifer M. Rusted, Robin G. Morris, Linda Clare

Published in: BMC Geriatrics | Issue 1/2024

Login to get access

Abstract

Background

Most people with dementia have multiple health conditions. This study explores (1) number and type of health condition(s) in people with dementia overall and in relation to age, sex, dementia type, and cognition; (2) change in number of health conditions over two years; and (3) whether over time the number of health conditions at baseline is related to social isolation, loneliness, quality of life, and/or well-being.

Methods

Longitudinal data from the IDEAL (Improving the experience of Dementia and Enhancing Active Life) cohort were used. Participants comprised people with dementia (n = 1490) living in the community (at baseline) in Great Britain. Health conditions using the Charlson Comorbidity Index, cognition, social isolation, loneliness, quality of life, and well-being were assessed over two years. Mixed effects modelling was used.

Results

On average participants had 1.8 health conditions at baseline, excluding dementia; increasing to 2.5 conditions over two years. Those with vascular dementia or mixed (Alzheimer’s and vascular) dementia had more health conditions than those with Alzheimer’s disease. People aged ≥ 80 had more health conditions than those aged < 65 years. At baseline having more health conditions was associated with increased loneliness, poorer quality of life, and poorer well-being, but was either minimally or not associated with cognition, sex, and social isolation. Number of health conditions had either minimal or no influence on these variables over time.

Conclusions

People with dementia in IDEAL generally had multiple health conditions and those with more health conditions were lonelier, had poorer quality of life, and poorer well-being.
Appendix
Available only for authorised users
Literature
1.
go back to reference Alzheimer’s Disease International. #WhatsYourPLan Campaign Report 2021/2022. London: Alzheimer’s Disease International; 2023. Alzheimer’s Disease International. #WhatsYourPLan Campaign Report 2021/2022. London: Alzheimer’s Disease International; 2023.
2.
go back to reference World Health Organization. International Classification of Diseases, Eleventh Revision (ICD-11). Geneva: World Health Organization; 2021. World Health Organization. International Classification of Diseases, Eleventh Revision (ICD-11). Geneva: World Health Organization; 2021.
3.
go back to reference Browne J, Edwards DA, Rhodes KM, Brimicombe DJ, Payne RA. Association of comorbidity and health service usage among patients with dementia in the UK: a population-based study. BMJ Open. 2017;7(3):e012546.PubMedPubMedCentralCrossRef Browne J, Edwards DA, Rhodes KM, Brimicombe DJ, Payne RA. Association of comorbidity and health service usage among patients with dementia in the UK: a population-based study. BMJ Open. 2017;7(3):e012546.PubMedPubMedCentralCrossRef
4.
go back to reference Bunn F, Burn A-M, Goodman C, Rait G, Norton S, Robinson L, Schoeman J, Brayne C. Comorbidity and dementia: a scoping review of the literature. BMC Med. 2014;12(1):192.PubMedPubMedCentralCrossRef Bunn F, Burn A-M, Goodman C, Rait G, Norton S, Robinson L, Schoeman J, Brayne C. Comorbidity and dementia: a scoping review of the literature. BMC Med. 2014;12(1):192.PubMedPubMedCentralCrossRef
5.
go back to reference Fox C, Smith T, Maidment I, Hebding J, Madzima T, Cheater F, Cross J, Poland F, White J, Young J. The importance of detecting and managing comorbidities in people with dementia? Age Ageing. 2014;43(6):741–3.PubMedCrossRef Fox C, Smith T, Maidment I, Hebding J, Madzima T, Cheater F, Cross J, Poland F, White J, Young J. The importance of detecting and managing comorbidities in people with dementia? Age Ageing. 2014;43(6):741–3.PubMedCrossRef
6.
go back to reference Poblador-Plou B, Calderó n-Larrañaga A, Marta-Moreno J, Hancco-Saavedra J, Sicras-Mainar A, Soljak M. Comorbidity of dementia: a cross-sectional study of primary care older patients. BMC Psychiatry. 2014;14(1):84.PubMedPubMedCentralCrossRef Poblador-Plou B, Calderó n-Larrañaga A, Marta-Moreno J, Hancco-Saavedra J, Sicras-Mainar A, Soljak M. Comorbidity of dementia: a cross-sectional study of primary care older patients. BMC Psychiatry. 2014;14(1):84.PubMedPubMedCentralCrossRef
7.
go back to reference Nelis SM, Wu Y-T, Matthews FE, Martyr A, Quinn C, Rippon I, Rusted J, Thom JM, Kopelman MD, Hindle JV. The impact of co-morbidity on the quality of life of people with dementia: findings from the IDEAL study. Age Ageing. 2019;48(3):361–7.PubMedCrossRef Nelis SM, Wu Y-T, Matthews FE, Martyr A, Quinn C, Rippon I, Rusted J, Thom JM, Kopelman MD, Hindle JV. The impact of co-morbidity on the quality of life of people with dementia: findings from the IDEAL study. Age Ageing. 2019;48(3):361–7.PubMedCrossRef
8.
go back to reference Simon Gabriël B, Antje H, De Jan L, Frans Boch W, Bert V. Trends in prevalence and incidence of registered dementia and trends in multimorbidity among patients with dementia in general practice in Flanders, Belgium, 2000–2021: a registry-based, retrospective, longitudinal cohort study. BMJ Open. 2022;12(11):e063891.CrossRef Simon Gabriël B, Antje H, De Jan L, Frans Boch W, Bert V. Trends in prevalence and incidence of registered dementia and trends in multimorbidity among patients with dementia in general practice in Flanders, Belgium, 2000–2021: a registry-based, retrospective, longitudinal cohort study. BMJ Open. 2022;12(11):e063891.CrossRef
9.
go back to reference Calderón-Larrañaga A, Vetrano DL, Onder G, Gimeno-Feliu LA, Coscollar-Santaliestra C, Carfí A, Pisciotta MS, Angleman S, Melis RJF, Santoni G, et al. Assessing and measuring chronic multimorbidity in the older population: a proposal for its operationalization. J Gerontol A Biol Sci Med Sci. 2017;72(10):1417–23.PubMed Calderón-Larrañaga A, Vetrano DL, Onder G, Gimeno-Feliu LA, Coscollar-Santaliestra C, Carfí A, Pisciotta MS, Angleman S, Melis RJF, Santoni G, et al. Assessing and measuring chronic multimorbidity in the older population: a proposal for its operationalization. J Gerontol A Biol Sci Med Sci. 2017;72(10):1417–23.PubMed
10.
go back to reference Doraiswamy PM, Leon J, Cummings JL, Marin D, Neumann PJ. Prevalence and impact of medical comorbidity in Alzheimer’s disease. J Gerontol A Biol Sci Med Sci. 2002;57(3):M173–7.PubMedCrossRef Doraiswamy PM, Leon J, Cummings JL, Marin D, Neumann PJ. Prevalence and impact of medical comorbidity in Alzheimer’s disease. J Gerontol A Biol Sci Med Sci. 2002;57(3):M173–7.PubMedCrossRef
11.
go back to reference Chowdhury SR, Das DC, Sunna TC, Beyene J, Hossain A. Global and regional prevalence of multimorbidity in the adult population in community settings: a systematic review and meta-analysis. Eclinicalmedicine. 2023;57:101860.PubMedPubMedCentralCrossRef Chowdhury SR, Das DC, Sunna TC, Beyene J, Hossain A. Global and regional prevalence of multimorbidity in the adult population in community settings: a systematic review and meta-analysis. Eclinicalmedicine. 2023;57:101860.PubMedPubMedCentralCrossRef
12.
go back to reference Tadros G, Salama RA, Kingston P, Mustafa N, Johnson E, Pannell R, Hashmi M. Impact of an integrated rapid response psychiatric liaison team on quality improvement and cost savings: the Birmingham RAID model. Psychiatrist. 2013;37(1):4–10.CrossRef Tadros G, Salama RA, Kingston P, Mustafa N, Johnson E, Pannell R, Hashmi M. Impact of an integrated rapid response psychiatric liaison team on quality improvement and cost savings: the Birmingham RAID model. Psychiatrist. 2013;37(1):4–10.CrossRef
13.
go back to reference Thorpe CT, Thorpe JM, Kind AJH, Bartels CM, Everett CM, Smith MA. Receipt of monitoring of diabetes mellitus in older adults with comorbid dementia. J Am Geriatr Soc. 2012;60(4):644–51.PubMedPubMedCentralCrossRef Thorpe CT, Thorpe JM, Kind AJH, Bartels CM, Everett CM, Smith MA. Receipt of monitoring of diabetes mellitus in older adults with comorbid dementia. J Am Geriatr Soc. 2012;60(4):644–51.PubMedPubMedCentralCrossRef
14.
go back to reference Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, Ballard C, Banerjee S, Burns A, Cohen-Mansfield J. Dementia prevention, intervention, and care. Lancet. 2017;390(10113):2673–734.PubMedCrossRef Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, Ballard C, Banerjee S, Burns A, Cohen-Mansfield J. Dementia prevention, intervention, and care. Lancet. 2017;390(10113):2673–734.PubMedCrossRef
15.
go back to reference Volicer L, Hurley AC. Management of behavioral symptoms in progressive degenerative dementias. J Gerontol A Biol Sci Med Sci. 2003;58(9):M837–45.PubMedCrossRef Volicer L, Hurley AC. Management of behavioral symptoms in progressive degenerative dementias. J Gerontol A Biol Sci Med Sci. 2003;58(9):M837–45.PubMedCrossRef
16.
go back to reference Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: Implications for improved targeting and care. J Gerontol A Biol Sci Med Sci. 2004;59(3):M255–63.CrossRef Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: Implications for improved targeting and care. J Gerontol A Biol Sci Med Sci. 2004;59(3):M255–63.CrossRef
17.
go back to reference Martyr A, Nelis SM, Quinn C, Wu Y-T, Lamont RA, Henderson C, Clarke R, Hindle JV, Thom JM, Jones IR, et al. Living well with dementia: a systematic review and correlational meta-analysis of factors associated with quality of life, well-being and life satisfaction in people with dementia. Psychol Med. 2018;48(13):2130–9.PubMedCrossRef Martyr A, Nelis SM, Quinn C, Wu Y-T, Lamont RA, Henderson C, Clarke R, Hindle JV, Thom JM, Jones IR, et al. Living well with dementia: a systematic review and correlational meta-analysis of factors associated with quality of life, well-being and life satisfaction in people with dementia. Psychol Med. 2018;48(13):2130–9.PubMedCrossRef
18.
go back to reference Aldridge H, Fisher P, Laidlaw K. Experiences of shame for people with dementia: an Interpretative phenomenological analysis. Dementia. 2017;18(5):1896–911.PubMedCrossRef Aldridge H, Fisher P, Laidlaw K. Experiences of shame for people with dementia: an Interpretative phenomenological analysis. Dementia. 2017;18(5):1896–911.PubMedCrossRef
19.
go back to reference Liao W, Hamel REG, Olde Rikkert MGM, Oosterveld SM, Aalten P, Verhey FRJ, Scheltens P, Sistermans N, Pijnenburg YAL, van der Flier WM, et al. A profile of the clinical course of cognition and comorbidity in Mild Cognitive Impairment and Dementia Study (The 4C study): Two complementary longitudinal, clinical cohorts in the Netherlands. BMC Neurol. 2016;16(1):242.PubMedPubMedCentralCrossRef Liao W, Hamel REG, Olde Rikkert MGM, Oosterveld SM, Aalten P, Verhey FRJ, Scheltens P, Sistermans N, Pijnenburg YAL, van der Flier WM, et al. A profile of the clinical course of cognition and comorbidity in Mild Cognitive Impairment and Dementia Study (The 4C study): Two complementary longitudinal, clinical cohorts in the Netherlands. BMC Neurol. 2016;16(1):242.PubMedPubMedCentralCrossRef
20.
go back to reference Schubert CC, Boustani M, Callahan CM, Perkins AJ, Carney CP, Fox C, Unverzagt F, Hui S, Hendrie HC. Comorbidity profile of dementia patients in primary care: are they sicker? J Am Geriatr Soc. 2006;54(1):104–9.PubMedCrossRef Schubert CC, Boustani M, Callahan CM, Perkins AJ, Carney CP, Fox C, Unverzagt F, Hui S, Hendrie HC. Comorbidity profile of dementia patients in primary care: are they sicker? J Am Geriatr Soc. 2006;54(1):104–9.PubMedCrossRef
21.
go back to reference Svendsboe E, Terum T, Testad I, Aarsland D, Ulstein I, Corbett A, Rongve A. Caregiver burden in family carers of people with dementia with Lewy bodies and Alzheimer’s disease. Int J Geriatr Psychiatry. 2016;31(9):1075–83.PubMedCrossRef Svendsboe E, Terum T, Testad I, Aarsland D, Ulstein I, Corbett A, Rongve A. Caregiver burden in family carers of people with dementia with Lewy bodies and Alzheimer’s disease. Int J Geriatr Psychiatry. 2016;31(9):1075–83.PubMedCrossRef
22.
go back to reference Griffith LE, Gruneir A, Fisher K, Panjwani D, Gandhi S, Sheng L, Gafni A, Patterson C, Markle-Reid M, Ploeg J. Patterns of health service use in community living older adults with dementia and comorbid conditions: a population-based retrospective cohort study in Ontario. Canada BMC Geriatrics. 2016;16(1):1–10. Griffith LE, Gruneir A, Fisher K, Panjwani D, Gandhi S, Sheng L, Gafni A, Patterson C, Markle-Reid M, Ploeg J. Patterns of health service use in community living older adults with dementia and comorbid conditions: a population-based retrospective cohort study in Ontario. Canada BMC Geriatrics. 2016;16(1):1–10.
23.
go back to reference Zhao Y, Kuo T-C, Weir S, Kramer MS, Ash AS. Healthcare costs and utilization for Medicare beneficiaries with Alzheimer’s. BMC Health Serv Res. 2008;8(1):1–8.CrossRef Zhao Y, Kuo T-C, Weir S, Kramer MS, Ash AS. Healthcare costs and utilization for Medicare beneficiaries with Alzheimer’s. BMC Health Serv Res. 2008;8(1):1–8.CrossRef
24.
go back to reference Bynum JPW, Rabins PV, Weller W, Niefeld M, Anderson GF, Wu AW. The relationship between a dementia diagnosis, chronic illness, medicare expenditures, and hospital use. J Am Geriatr Soc. 2004;52(2):187–94.PubMedCrossRef Bynum JPW, Rabins PV, Weller W, Niefeld M, Anderson GF, Wu AW. The relationship between a dementia diagnosis, chronic illness, medicare expenditures, and hospital use. J Am Geriatr Soc. 2004;52(2):187–94.PubMedCrossRef
25.
go back to reference Hill JW, Futterman R, Duttagupta S, Mastey V, Lloyd JR, Fillit HM. Alzheimer’s disease and related dementias increase costs of comorbidities in managed Medicare. Neurology. 2002;58(1):62–70.PubMedCrossRef Hill JW, Futterman R, Duttagupta S, Mastey V, Lloyd JR, Fillit HM. Alzheimer’s disease and related dementias increase costs of comorbidities in managed Medicare. Neurology. 2002;58(1):62–70.PubMedCrossRef
26.
go back to reference Zhu CW, Cosentino S, Ornstein KA, Gu Y, Andrews H, Stern Y. Interactive effects of dementia severity and comorbidities on medicare expenditures. J Alzheimers Dis. 2017;57(1):305–15.PubMedPubMedCentralCrossRef Zhu CW, Cosentino S, Ornstein KA, Gu Y, Andrews H, Stern Y. Interactive effects of dementia severity and comorbidities on medicare expenditures. J Alzheimers Dis. 2017;57(1):305–15.PubMedPubMedCentralCrossRef
27.
go back to reference Henderson C, Knapp M, Martyr A, Gamble LD, Nelis SM, Quinn C, Pentecost C, Collins R, Wu Y-T, Jones IR. The use and costs of paid and unpaid care for people with dementia: longitudinal findings from the IDEAL cohort. J Alzheimers Dis. 2022;86(1):135–53.PubMedCrossRef Henderson C, Knapp M, Martyr A, Gamble LD, Nelis SM, Quinn C, Pentecost C, Collins R, Wu Y-T, Jones IR. The use and costs of paid and unpaid care for people with dementia: longitudinal findings from the IDEAL cohort. J Alzheimers Dis. 2022;86(1):135–53.PubMedCrossRef
29.
go back to reference Zekry D, Herrmann FR, Graf CE, Giannelli S, Michel J-P, Gold G, Krause K-H. High levels of comorbidity and disability cancel out the dementia effect in predictions of long-term mortality after discharge in the very old. Dement Geriatr Cogn Disord. 2011;32(2):103–10.PubMedCrossRef Zekry D, Herrmann FR, Graf CE, Giannelli S, Michel J-P, Gold G, Krause K-H. High levels of comorbidity and disability cancel out the dementia effect in predictions of long-term mortality after discharge in the very old. Dement Geriatr Cogn Disord. 2011;32(2):103–10.PubMedCrossRef
30.
go back to reference Gierveld JD, Tilburg TV. A 6-item scale for overall, emotional, and social loneliness: confirmatory tests on survey data. Res Aging. 2006;28(5):582–98.CrossRef Gierveld JD, Tilburg TV. A 6-item scale for overall, emotional, and social loneliness: confirmatory tests on survey data. Res Aging. 2006;28(5):582–98.CrossRef
31.
go back to reference Lubben J, Blozik E, Gillmann G, Iliffe S, von Renteln KW, Beck JC, Stuck AE. Performance of an abbreviated version of the Lubben Social Network Scale among three European community-dwelling older adult populations. Gerontologist. 2006;46(4):503–13.PubMedCrossRef Lubben J, Blozik E, Gillmann G, Iliffe S, von Renteln KW, Beck JC, Stuck AE. Performance of an abbreviated version of the Lubben Social Network Scale among three European community-dwelling older adult populations. Gerontologist. 2006;46(4):503–13.PubMedCrossRef
32.
go back to reference Victor CR, Rippon I, Nelis SM, Martyr A, Litherland R, Pickett J, Hart N, Henley J, Matthews F, Clare L. Prevalence and determinants of loneliness in people living with dementia: findings from the IDEAL programme. Int J Geriatr Psychiatry. 2020;35(8):851–8.PubMedCrossRef Victor CR, Rippon I, Nelis SM, Martyr A, Litherland R, Pickett J, Hart N, Henley J, Matthews F, Clare L. Prevalence and determinants of loneliness in people living with dementia: findings from the IDEAL programme. Int J Geriatr Psychiatry. 2020;35(8):851–8.PubMedCrossRef
33.
go back to reference Clare L, Nelis SM, Quinn C, Martyr A, Henderson C, Hindle JV, Jones IR, Jones RW, Knapp M, Kopelman MD. Improving the experience of dementia and enhancing active life-living well with dementia: study protocol for the IDEAL study. Health Qual Life Outcomes. 2014;12(1):164–73.PubMedPubMedCentralCrossRef Clare L, Nelis SM, Quinn C, Martyr A, Henderson C, Hindle JV, Jones IR, Jones RW, Knapp M, Kopelman MD. Improving the experience of dementia and enhancing active life-living well with dementia: study protocol for the IDEAL study. Health Qual Life Outcomes. 2014;12(1):164–73.PubMedPubMedCentralCrossRef
34.
go back to reference Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–98.PubMedCrossRef Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–98.PubMedCrossRef
35.
go back to reference Charlson ME, Charlson RE, Peterson JC, Marinopoulos SS, Briggs WM, Hollenberg JP. The Charlson comorbidity index is adapted to predict costs of chronic disease in primary care patients. J Clin Epidemiol. 2008;61(12):1234–40.PubMedCrossRef Charlson ME, Charlson RE, Peterson JC, Marinopoulos SS, Briggs WM, Hollenberg JP. The Charlson comorbidity index is adapted to predict costs of chronic disease in primary care patients. J Clin Epidemiol. 2008;61(12):1234–40.PubMedCrossRef
36.
go back to reference Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis. 1987;40(5):373–83.PubMedCrossRef Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis. 1987;40(5):373–83.PubMedCrossRef
37.
go back to reference Clare L, Martyr A, Henderson C, Gamble LD, Matthews FE, Quinn C, Nelis SM, Rusted J, Thom J, Knapp M, et al. Living alone with mild-to-moderate dementia: findings from the IDEAL cohort. J Alzheimers Dis. 2020;78(3):1207–16.PubMedCrossRef Clare L, Martyr A, Henderson C, Gamble LD, Matthews FE, Quinn C, Nelis SM, Rusted J, Thom J, Knapp M, et al. Living alone with mild-to-moderate dementia: findings from the IDEAL cohort. J Alzheimers Dis. 2020;78(3):1207–16.PubMedCrossRef
38.
go back to reference Wu YT, Clare L, Hindle JV, Nelis SM, Martyr A, Matthews FE. Dementia subtype and living well: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study. BMC Med. 2018;16(1):140.PubMedPubMedCentralCrossRef Wu YT, Clare L, Hindle JV, Nelis SM, Martyr A, Matthews FE. Dementia subtype and living well: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study. BMC Med. 2018;16(1):140.PubMedPubMedCentralCrossRef
39.
go back to reference Hiltunen K, Saarela RKT, Kautiainen H, Roitto H-M, Pitkälä KH, Mäntylä P. Relationship between Fried’s frailty phenotype and oral frailty in long-term care residents. Age Ageing. 2021;50(6):2133–9.PubMedPubMedCentralCrossRef Hiltunen K, Saarela RKT, Kautiainen H, Roitto H-M, Pitkälä KH, Mäntylä P. Relationship between Fried’s frailty phenotype and oral frailty in long-term care residents. Age Ageing. 2021;50(6):2133–9.PubMedPubMedCentralCrossRef
40.
go back to reference Logsdon RG, Gibbons LE, McCurry SM, Teri L. Quality of life in Alzheimer’s disease: Patient and caregiver reports. In: Albert SM, editor. Assessing Quality of Life in Dementia. Logsdon RG: Springer; 2000. p. 17–30. Logsdon RG, Gibbons LE, McCurry SM, Teri L. Quality of life in Alzheimer’s disease: Patient and caregiver reports. In: Albert SM, editor. Assessing Quality of Life in Dementia. Logsdon RG: Springer; 2000. p. 17–30.
41.
go back to reference Bech P. Measuring the dimension of psychological general well-being by the WHO-5. Qual Life Newsl. 2004;32(1):15–6. Bech P. Measuring the dimension of psychological general well-being by the WHO-5. Qual Life Newsl. 2004;32(1):15–6.
42.
go back to reference Clarke C, Woods B, Moniz-Cook E, Mountain G, Øksnebjerg L, Chattat R, Diaz A, Gove D, Vernooij-Dassen M, Wolverson E. Measuring the well-being of people with dementia: a conceptual scoping review. Health Qual Life Outcomes. 2020;18(1):249.PubMedPubMedCentralCrossRef Clarke C, Woods B, Moniz-Cook E, Mountain G, Øksnebjerg L, Chattat R, Diaz A, Gove D, Vernooij-Dassen M, Wolverson E. Measuring the well-being of people with dementia: a conceptual scoping review. Health Qual Life Outcomes. 2020;18(1):249.PubMedPubMedCentralCrossRef
43.
go back to reference Hajek A, Kretzler B, König H-H. Multimorbidity, loneliness, and social isolation. A systematic review. Int J Environ Res Public Health. 2020;17(22):8688. Hajek A, Kretzler B, König H-H. Multimorbidity, loneliness, and social isolation. A systematic review. Int J Environ Res Public Health. 2020;17(22):8688.
44.
go back to reference StataCorp: Stata Statistical Software: Release 17. College Station; 2021. StataCorp: Stata Statistical Software: Release 17. College Station; 2021.
45.
go back to reference Kingston A, Robinson L, Booth H, Knapp M, Jagger C. for the Modem project: projections of multi-morbidity in the older population in England to 2035: estimates from the Population Ageing and Care Simulation (PACSim) model. Age Ageing. 2018;47(3):374–80.PubMedPubMedCentralCrossRef Kingston A, Robinson L, Booth H, Knapp M, Jagger C. for the Modem project: projections of multi-morbidity in the older population in England to 2035: estimates from the Population Ageing and Care Simulation (PACSim) model. Age Ageing. 2018;47(3):374–80.PubMedPubMedCentralCrossRef
46.
47.
go back to reference Turner G, Clegg A. Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report. Age Ageing. 2014;43(6):744–7.PubMedCrossRef Turner G, Clegg A. Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report. Age Ageing. 2014;43(6):744–7.PubMedCrossRef
48.
go back to reference Formiga F, Fort I, Robles MJ, Riu S, Rodrìguez D, Sabartes O. Aspectos diferenciales de comorbilidad en pacientes ancianos con demencia tipo Alzheimer o con demencia vascular. In: Revista de NeurologÌa. 2008;46:72–76. Formiga F, Fort I, Robles MJ, Riu S, Rodrìguez D, Sabartes O. Aspectos diferenciales de comorbilidad en pacientes ancianos con demencia tipo Alzheimer o con demencia vascular. In: Revista de NeurologÌa. 2008;46:72–76.
49.
go back to reference Scrutton J, Brancati CU. Dementia and comorbidities: ensuring parity of care. London: International Longevity Centre; 2016. Scrutton J, Brancati CU. Dementia and comorbidities: ensuring parity of care. London: International Longevity Centre; 2016.
50.
go back to reference Hale MD, Santorelli G, Brundle C, Clegg A. A cross-sectional study assessing agreement between self-reported and general practice-recorded health conditions among community dwelling older adults. Age Ageing. 2020;49(1):135–40.CrossRef Hale MD, Santorelli G, Brundle C, Clegg A. A cross-sectional study assessing agreement between self-reported and general practice-recorded health conditions among community dwelling older adults. Age Ageing. 2020;49(1):135–40.CrossRef
Metadata
Title
Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme
Authors
Serena Sabatini
Anthony Martyr
Anna Hunt
Laura D. Gamble
Fiona E. Matthews
Jeanette M. Thom
Roy W. Jones
Louise Allan
Martin Knapp
Christina Victor
Claire Pentecost
Jennifer M. Rusted
Robin G. Morris
Linda Clare
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2024
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-023-04601-x

Other articles of this Issue 1/2024

BMC Geriatrics 1/2024 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine