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Journal of Cardiovascular Translational Research

Published in:

Open Access 01-10-2013

Coronary Flow Reserve from Mouse to Man—from Mechanistic Understanding to Future Interventions

Authors: Li-Ming Gan, Johannes Wikström, Regina Fritsche-Danielson

Published in: Journal of Cardiovascular Translational Research | Issue 5/2013

Abstract

Myocardial ischemia is recognized as an important mechanism increasing the risk for cardiovascular events in both symptomatic and asymptomatic patients. In addition to obstructive coronary diseases, systemic inflammation, macro- and microvascular function are additional important mechanisms contributing to the ischemic myocardium. Accumulating evidence indicates that coronary flow reserve (CFR) is a quantitative measurement of ischemia including integrated information on structure and function of the coronary artery at all levels. Not surprisingly, CFR has been shown to confer strong prognostic value for hard cardiovascular (CV) events in a number of relevant patient cohorts. Using high-resolution imaging, it is now possible to study coronary arteries from mouse to man. Therefore, CFR may be an important translational tool to risk-stratify patients and to perform both preclinical and clinical proof-of-concept studies before investing in large-scale outcome trials, thus improving the translational value for novel CV targets.

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Title: Coronary Flow Reserve from Mouse to Man—from Mechanistic Understanding to Future Interventions
Authors: Li-Ming Gan
Johannes Wikström
Regina Fritsche-Danielson
Publication date: 01-10-2013
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 5/2013
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-013-9497-5

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Coronary Flow Reserve from Mouse to Man—from Mechanistic Understanding to Future Interventions

Abstract

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Abstract

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