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European Radiology
Published in: European Radiology 3/2020

01-03-2020 | Computed Tomography | Computed Tomography

Single-slice CT measurements allow for accurate assessment of sarcopenia and body composition

Authors: David Zopfs, Sebastian Theurich, Nils Große Hokamp, Jana Knuever, Lukas Gerecht, Jan Borggrefe, Max Schlaak, Daniel Pinto dos Santos

Published in: European Radiology | Issue 3/2020

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Abstract

Objectives

To evaluate the correlation between simple planimetric measurements in axial computed tomography (CT) slices and measurements of patient body composition and anthropometric data performed with bioelectrical impedance analysis (BIA) and metric clinical assessments.

Methods

In this prospective cross-sectional study, we analyzed data of a cohort of 62 consecutive, untreated adult patients with advanced malignant melanoma who underwent concurrent BIA assessments at their radiologic baseline staging by CT between July 2016 and October 2017. To assess muscle and adipose tissue mass, we analyzed the areas of the paraspinal muscles as well as the cross-sectional total patient area in a single CT slice at the height of the third lumbar vertebra. These measurements were subsequently correlated with anthropometric (body weight) and body composition parameters derived from BIA (muscle mass, fat mass, fat-free mass, and visceral fat mass). Linear regression models were built to allow for estimation of each parameter based on CT measurements.

Results

Linear regression models allowed for accurate prediction of patient body weight (adjusted R2 = 0.886), absolute muscle mass (adjusted R2 = 0.866), fat-free mass (adjusted R2 = 0.855), and total as well as visceral fat mass (adjusted R2 = 0.887 and 0.839, respectively).

Conclusions

Our data suggest that patient body composition can accurately and quantitatively be determined by using simple measurements in a single axial CT slice. This could be useful in various medical and scientific settings, where the knowledge of the patient’s anthropometric parameters is not immediately or easily available.

Key Points

• Easy to perform measurements on a single CT slice highly correlate with clinically valuable parameters of body composition.
• Body composition data were acquired using bioelectrical impedance analysis to correlate CT measurements with a non-imaging-based method, which is frequently lacking in previous studies.
• The obtained equations facilitate a quick, opportunistic assessment of relevant parameters of body composition.
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Metadata
Title
Single-slice CT measurements allow for accurate assessment of sarcopenia and body composition
Authors
David Zopfs
Sebastian Theurich
Nils Große Hokamp
Jana Knuever
Lukas Gerecht
Jan Borggrefe
Max Schlaak
Daniel Pinto dos Santos
Publication date
01-03-2020
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 3/2020
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06526-9

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