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Abdominal Radiology
Published in: Abdominal Radiology 8/2019

01-08-2019 | Computed Tomography | Hepatobiliary

Microvascular invasion and grading in hepatocellular carcinoma: correlation with major and ancillary features according to LIRADS

Authors: Vincenza Granata, Roberta Fusco, Sergio Venanzio Setola, Carmine Picone, Paolo Vallone, Andrea Belli, Paola Incollingo, Vittorio Albino, Fabiana Tatangelo, Francesco Izzo, Antonella Petrillo

Published in: Abdominal Radiology | Issue 8/2019

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Abstract

Purpose

To assess major and ancillary parameters that could be correlated with Microvascular Invasion (MIV) and with histologic grade of HCC.

Materials and methods

In this retrospective study, we assessed 62 patients (14 women–48 men; mean age, 63 years; range 38–80 years) that underwent hepatic resection for HCC. All patients were subject to Multidetector computed tomography (MDCT); 40 to Magnetic Resonance (MR) study. The radiologist assessed major and ancillary features according to LIRADS (v. 2018) and reported any radiological accessory findings if detected.

Results

No major feature showed statistically significant differences and correlation with grading. Mean ADC value was correlated with grading and with MIV status. No major feature was correlated to MIV; progressive contrast enhancement and satellite nodules showed statistically different percentages with respect to the presence of MIV, so as at the monovariate correlation analysis, satellite nodules were correlated with the presence of MIV. At multivariate regression analysis, no factor proved to be strong predictors of grading while progressive contrast enhancement and satellite nodules were significantly associated with the MIV.

Conclusion

Mean ADC value is correlated to HCC grading and MIV status. Progressive contrast enhancement and the presence of satellite nodules are correlated to MIV status.
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Metadata
Title
Microvascular invasion and grading in hepatocellular carcinoma: correlation with major and ancillary features according to LIRADS
Authors
Vincenza Granata
Roberta Fusco
Sergio Venanzio Setola
Carmine Picone
Paolo Vallone
Andrea Belli
Paola Incollingo
Vittorio Albino
Fabiana Tatangelo
Francesco Izzo
Antonella Petrillo
Publication date
01-08-2019
Publisher
Springer US
Published in
Abdominal Radiology / Issue 8/2019
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-019-02056-6

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