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Open Access 01-12-2023 | Cervical Cancer | Original Article

A feasibility study of reduced full-of-view synthetic high-b-value diffusion-weighted imaging in uterine tumors

Authors: Qian Tang, Qiqi Zhou, Wen Chen, Ling Sang, Yu Xing, Chao Liu, Kejun Wang, Weiyin Vivian Liu, Lin Xu

Published in: Insights into Imaging | Issue 1/2023

Abstract

Objectives

This study aimed to evaluate the feasibility of reduced full-of-view synthetic high-b value diffusion-weighted images (rFOV-syDWIs) in the clinical application of cervical cancer based on image quality and diagnostic efficacy.

Methods

We retrospectively evaluated the data of 35 patients with cervical cancer and 35 healthy volunteers from May to November 2021. All patients and volunteers underwent rFOV-DWI scans, including a 13b-protocol: b = 0, 25, 50, 75, 100, 150, 200, 400, 600, 800, 1000, 1200, and 1500 s/mm² and a 5b-protocol: b = 0, 100, 400, 800,1500 s/mm². rFOV-syDWIs with b values of 1200 (rFOV-syDWI_b=1200) and 1500 (rFOV-syDWI_b=1500) were generated from two different multiple-b-value image datasets using a mono-exponential fitting algorithm. According to homoscedasticity and normality assessed by the Levene’s test and Shapiro–Wilk test, the inter-modality differences of quantitative measurements were, respectively, examined by Wilcoxon signed-rank test or paired t test and the inter-group differences of ADC values were examined by independent t test or Mann–Whitney U test.

Results

A higher inter-reader agreement between SNRs and CNRs was found in 13b-protocol and 5b-protocol rFOV-syDWI_b=1200/1500 compared to 13b-protocol rFOV-sDWI_b=1200/1500 (p < 0.05). AUC of 5b-protocol syADC_{mean,b=1200/1500} and syADC_{minimum,b=1200/1500} was equal or higher than that of 13b-protocol sADC_{mean,b=1200/1500} and sADC_{minimum,b=1200/1500}.

Conclusions

rFOV-syDWIs provide better lesion clarity and higher image quality than rFOV-sDWIs. 5b-protocol rFOV-syDWIs shorten scan time, and synthetic ADCs offer reliable diagnosis value as scanned 13b-protocol DWIs.

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Title: A feasibility study of reduced full-of-view synthetic high-b-value diffusion-weighted imaging in uterine tumors
Authors: Qian Tang
Qiqi Zhou
Wen Chen
Ling Sang
Yu Xing
Chao Liu
Kejun Wang
Weiyin Vivian Liu
Lin Xu
Publication date: 01-12-2023
Publisher: Springer Vienna
Keywords: Cervical Cancer
Cervical Cancer
Published in: Insights into Imaging / Issue 1/2023
Electronic ISSN: 1869-4101
DOI: https://doi.org/10.1186/s13244-022-01350-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A feasibility study of reduced full-of-view synthetic high-b-value diffusion-weighted imaging in uterine tumors

Abstract

Objectives

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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