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European Radiology
Published in: European Radiology 11/2013

01-11-2013 | Urogenital

Computed diffusion-weighted imaging of the prostate at 3 T: impact on image quality and tumour detection

Authors: Andrew B. Rosenkrantz, Hersh Chandarana, Nicole Hindman, Fang-Ming Deng, James S. Babb, Samir S. Taneja, Christian Geppert

Published in: European Radiology | Issue 11/2013

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Abstract

Objectives

To investigate the impact of prostate computed diffusion-weighted imaging (DWI) on image quality and tumour detection.

Methods

Forty-nine patients underwent 3-T magnetic resonance imaging using a pelvic phased-array coil before prostatectomy, including DWI with b values of 50 and 1,000 s/mm2. Computed DW images with b value 1,500 s/mm2 were generated from the lower b-value images. Directly acquired b-1,500 DW images were obtained in 39 patients. Two radiologists independently assessed DWI for image quality measures and location of the dominant lesion. A third radiologist measured tumour-to-peripheral-zone (PZ) contrast. Pathological findings from prostatectomy served as the reference standard.

Results

Direct and computed b-1,500 DWI showed better suppression of benign prostate tissue than direct b-1,000 DWI for both readers (P ≤ 0.024). However, computed b-1,500 DWI showed less distortion and ghosting than direct b-1,000 and direct b-1,500 DWI for both readers (P ≤ 0.067). Direct and computed b-1,500 images showed better sensitivity and positive predictive value (PPV) for tumour detection than direct b-1,000 images for both readers (P ≤ 0.062), with no difference in sensitivity or PPV between direct and computed b-1,500 images (P ≥ 0.180). Tumour-to-PZ contrast was greater on computed b-1,500 than on either direct DWI set (P < 0.001).

Conclusion

Computed DWI of the prostate using b value ≥1,000 s/mm2 improves image quality and tumour detection compared with acquired standard b-value images.

Key Points

• Diffusion weighted MRI is increasingly used for diagnosing and assessing prostate carcinoma.
• Prostate computed DWI can extrapolate high b-value images from lower b values.
• Computed DWI provides greater suppression of benign tissue than lower b-value images.
• Computed DWI provides less distortion and artefacts than images using same b value.
• Computed DWI provides better diagnostic performance than lower b-value images.
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Metadata
Title
Computed diffusion-weighted imaging of the prostate at 3 T: impact on image quality and tumour detection
Authors
Andrew B. Rosenkrantz
Hersh Chandarana
Nicole Hindman
Fang-Ming Deng
James S. Babb
Samir S. Taneja
Christian Geppert
Publication date
01-11-2013
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 11/2013
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-013-2917-8

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