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European Radiology
Published in: European Radiology 1/2005

01-01-2005 | Urogenital

Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix

Authors: Shinji Naganawa, Chiho Sato, Hisashi Kumada, Takeo Ishigaki, Shunichi Miura, Osamu Takizawa

Published in: European Radiology | Issue 1/2005

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Abstract

A relation between apparent diffusion coefficient (ADC) values and tumor cellular density has been reported. The purpose of this study was to measure the ADC values of cervical cancers in the uterus and compare them with those of normal cervical tissues, and to test whether ADC could differentiate between normal and malignant cervical tissues in the uterus. Twelve consecutive female patients with cervical cancer of the uterus and ten female patients with other pelvic abnormalities were included in this study. ADC was measured at 1.5 T with b-factors of 0, 300 and 600 s/mm2 using single-shot echo-planar diffusion-weighted imaging and a parallel imaging technique. The mean ADC value of cervical cancer lesions was 1.09±0.20×10−3 mm2/s, and that of normal cervix tissue was 1.79±0.24×10−3 mm2/s (P<0.0001). In nine patients treated by chemotherapy and/or radiation therapy, the mean ADC value of the cervical cancer lesion increased significantly after therapy (P<0.001). The present study showed, with a small number of patients, that ADC measurement has a potential ability to differentiate between normal and cancerous tissue in the uterine cervix. Further study is necessary to determine the accuracy of ADC measurement in monitoring the treatment response.
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Metadata
Title
Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix
Authors
Shinji Naganawa
Chiho Sato
Hisashi Kumada
Takeo Ishigaki
Shunichi Miura
Osamu Takizawa
Publication date
01-01-2005
Publisher
Springer-Verlag
Published in
European Radiology / Issue 1/2005
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-004-2529-4

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