Issue 2/2024
Content (21 Articles)
From basic research to clinical application: targeting fibroblast activation protein for cancer diagnosis and treatment
Zeyu Zhang, Jinxin Tao, Jiangdong Qiu, Zhe Cao, Hua Huang, Jianchun Xiao, Taiping Zhang
Fibroblast subtypes in pancreatic cancer and pancreatitis: from mechanisms to therapeutic strategies
Huizhen Huang, Wanyi Lu, Xiuli Zhang, Jiachun Pan, Feng Cao, Li Wen
The microbiota and renal cell carcinoma
Ke Wu, Yaorong Li, Kangli Ma, Weiguang Zhao, Zhixian Yao, Zhong Zheng, Feng Sun, Xingyu Mu, Zhihong Liu, Junhua Zheng
Targeting the lipid metabolic reprogramming of tumor-associated macrophages: A novel insight into cancer immunotherapy
Liang Li, Si-Rui Ma, Zi-Li Yu
Redox signaling-mediated tumor extracellular matrix remodeling: pleiotropic regulatory mechanisms
Guowen Liu, Bowen Li, Siyuan Qin, Edouard C. Nice, Jinlin Yang, Li Yang, Canhua Huang
Immune characteristics associated with lymph node metastasis in early-stage NSCLC
Ziyu Zhang, Li Li, Yang Gao, Xiaoxiong Xiao, Liyan Ji, Zhipeng Zhou, Juan Jiang, Shiqing Liu, Jian An, Pengbo Deng, NanNan Du, Pansong Li, Xuefeng Xia, Chengping Hu, Min Li
Notum enhances gastric cancer stem-like cell properties through upregulation of Sox2 by PI3K/AKT signaling pathway
Yi Liu, Hui Chen, Lanshu Xiao, Ping Dong, Yanhui Ma, Yunlan Zhou, Junyao Yang, Bingxian Bian, Guohua Xie, Lei Chen, Lisong Shen
Identifying the effectiveness of 3D culture systems to recapitulate breast tumor tissue in situ
Katarzyna A. Ludwik, Frances R. Greathouse, Samuel Han, Kimberly Stauffer, David R. Brenin, Thomas P. Stricker, Deborah A. Lannigan
Neuropilin-2 acts a critical determinant for epithelial-to-mesenchymal transition and aggressive behaviors of human head and neck cancer
Min-Hye Ahn, Ji-Hoon Kim, Su-Jung Choi, Hyun-Ji Kim, Dong-Guk Park, Kyu-Young Oh, Hye-Jung Yoon, Seong-Doo Hong, Jae-Il Lee, Ji-Ae Shin, Sung-Dae Cho
SUMOylation inhibitors activate anti-tumor immunity by reshaping the immune microenvironment in a preclinical model of hepatocellular carcinoma
Zengbin Wang, Banglun Pan, Lili Su, Huahui Yu, Xiaoxuan Wu, Yuxin Yao, Xiaoxia Zhang, Jiacheng Qiu, Nanhong Tang
Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer
Ellen Finnegan, Wei Ding, Ziga Ude, Sara Terer, Tadhg McGivern, Anna M. Blümel, Grainne Kirwan, Xinxin Shao, Flavia Genua, Xiaofei Yin, Alexander Kel, Sarinj Fattah, Parvathi A. Myer, Sally-Ann Cryan, Jochen H. M. Prehn, Darran P. O’Connor, Lorraine Brennan, Gregory Yochum, Celine J. Marmion, Sudipto Das
Plasma cell signatures predict prognosis and treatment efficacy for lung adenocarcinoma
Long Shu, Jun Tang, Shuang Liu, Yongguang Tao
High-plex spatial transcriptomic profiling reveals distinct immune components and the HLA class I/DNMT3A/CD8 modulatory axis in mismatch repair-deficient endometrial cancer
Jingjing Guo, Baijie Tang, Jing Fu, Xuan Zhu, Wenlong Xie, Nan Wang, Zhiyong Ding, Zhentao Song, Yue Yang, Gang Xu, Xue Xiao
Identifying cancer subtypes based on embryonic and hematopoietic stem cell signatures in pan-cancer
Jiali Lei, Jiangti Luo, Qian Liu, Xiaosheng Wang
Inhibition of thioredoxin-1 enhances the toxicity of glycolysis inhibitor 2-deoxyglucose by downregulating SLC1A5 expression in colorectal cancer cells
Tianbin Tang, Daoquan Fang, Ziwei Ji, Zuyue Zhong, Baojian Zhou, Lechi Ye, Lei Jiang, Xuecheng Sun
FAP is a prognostic marker, but not a viable therapeutic target for clinical translation in HNSCC
Jie Liu, Yeling Ouyang, Zijin Xia, Wenhao Mai, Hongrui Song, Fang Zhou, Lichun Shen, Kaiting Chen, Xiaochen Li, Shi-Min Zhuang, Jing Liao
Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis
Hong-Juan You, Li-Hong Ma, Xing Wang, Yu-Xin Wang, Huan-Yang Zhang, En-Si Bao, Yu-Jie Zhong, Xiang-Ye Liu, De-Long Kong, Kui-Yang Zheng, Fan-Yun Kong, Ren-Xian Tang
Cancer/testis-45A1 promotes cervical cancer cell tumorigenesis and drug resistance by activating oncogenic SRC and downstream signaling pathways
Mei Meng, Yan Guo, Yu Chen, Xu Li, Bin Zhang, Zhijia Xie, Juntao Liu, Zhe Zhao, Yuxi Liu, Tong Zhang, Yingnan Qiao, Bingxue Shang, Quansheng Zhou
Exploration of molecular markers related to chemotherapy efficacy of hepatoid adenocarcinoma of the stomach
Jingtao Wei, Ke Ji, Yue Zhang, Ji Zhang, Xiaojiang Wu, Xin Ji, Kai Zhou, Xuesong Yang, Hongfeng Lu, Anqiang Wang, Zhaode Bu
The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer
Cristina Di Giorgio, Rachele Bellini, Antonio Lupia, Carmen Massa, Ginevra Urbani, Martina Bordoni, Silvia Marchianò, Rosalinda Rosselli, Rosa De Gregorio, Pasquale Rapacciuolo, Valentina Sepe, Elva Morretta, Maria Chiara Monti, Federica Moraca, Luigi Cari, Khan Rana Sami Ullah, Nicola Natalizi, Luigina Graziosi, Eleonora Distrutti, Michele Biagioli, Bruno Catalanotti, Annibale Donini, Angela Zampella, Stefano Fiorucci
Feature-weight based measurement of cancerous transcriptome using cohort-wide and sample-specific information
Qilu Wang, Jiaoyang Jessie Song, Feng Zhang