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Published in: Current HIV/AIDS Reports 4/2019

01-08-2019 | Care | Implementation Science (E Geng, Section Editor)

Interventions to Improve Linkage to HIV Care in the Era of “Treat All” in Sub-Saharan Africa: a Systematic Review

Authors: Nicole Kelly, Werner Maokola, Omobola Mudasiru, Sandra I. McCoy

Published in: Current HIV/AIDS Reports | Issue 4/2019

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Abstract

Purpose of the Review

In 2015, antiretroviral therapy (ART) was recommended for all people living with HIV (PLHIV) regardless of CD4 count (“Treat All”). To better understand how to improve linkage to care under these new guidelines, we conducted a systematic review of studies evaluating linkage interventions in Sub-Saharan Africa under Treat All.

Recent Findings

We identified 14 eligible articles and qualitatively analyzed the effectiveness of the interventions. Increases in linkage were reported by supply-side and counseling interventions. Mobile testing and economic incentives did not increase linkage.

Summary

Given the lag time between adoption and implementation, only two of the studies were conducted in a Treat All setting. None of the interventions specifically focused on re-linking PLHIV who had disengaged from care. Future studies must design interventions that target not only newly diagnosed or treatment naïve PLHIV, but should explicitly focus on PLHIV who have disengaged from care.
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Literature
1.
go back to reference Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. WHO: World Health Organization; 2015. Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. WHO: World Health Organization; 2015.
5.
go back to reference • Miles to Go…. In: UNAIDS. Miles to go: closing gaps breaking barriers righting injustices. UNAIDS; 2018. https://doi.org/10.1111/j.1600-6143.2011.03542.x. This report highlights global and regional gaps in linkage to HIV care by providing current estimates of PLHIV who are not accessing ART despite all PLHIV being eligible under Treat All. • Miles to Go…. In: UNAIDS. Miles to go: closing gaps breaking barriers righting injustices. UNAIDS; 2018. https://​doi.​org/​10.​1111/​j.​1600-6143.​2011.​03542.​x. This report highlights global and regional gaps in linkage to HIV care by providing current estimates of PLHIV who are not accessing ART despite all PLHIV being eligible under Treat All.
21.
26.
go back to reference Ruzagira E, Baisley K, Kamali A, Biraro S, Grosskurth H. Working group on linkage to HIVC. Linkage to HIV care after home-based HIV counselling and testing in sub-Saharan Africa: a systematic review. Tropical Med Int Health. 2017;22(7):807–21. https://doi.org/10.1111/tmi.12888.CrossRef Ruzagira E, Baisley K, Kamali A, Biraro S, Grosskurth H. Working group on linkage to HIVC. Linkage to HIV care after home-based HIV counselling and testing in sub-Saharan Africa: a systematic review. Tropical Med Int Health. 2017;22(7):807–21. https://​doi.​org/​10.​1111/​tmi.​12888.CrossRef
30.
go back to reference Proctor E, Silmere H, Raghavan R, Hovmand P, Aarons G, Bunger A, et al. Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda. Admin Pol Ment Health. 2010;38(2):65–76.CrossRef Proctor E, Silmere H, Raghavan R, Hovmand P, Aarons G, Bunger A, et al. Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda. Admin Pol Ment Health. 2010;38(2):65–76.CrossRef
32.
go back to reference Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.handbook.cochrane.org. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.​handbook.​cochrane.​org.
33.
go back to reference Use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants. WHO: World Health Organization; 2012. Use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants. WHO: World Health Organization; 2012.
35.
go back to reference The Republic of Uganda Ministry of Health. Consolidated guidelines for prevention and treatment of HIV in Uganda.; 2016. The Republic of Uganda Ministry of Health. Consolidated guidelines for prevention and treatment of HIV in Uganda.; 2016.
36.
go back to reference The Zambian Ministry of Health. Zambia consolidated guidelines for treatment and prevention of HIV infection.; 2014. The Zambian Ministry of Health. Zambia consolidated guidelines for treatment and prevention of HIV infection.; 2014.
37.
go back to reference Ministry of Health; National AIDS and STI Control Program (NASCOP). Guidelines on use of antiretroviral drugs for treating and preventing HIV infection: a rapid advice; 2014. Ministry of Health; National AIDS and STI Control Program (NASCOP). Guidelines on use of antiretroviral drugs for treating and preventing HIV infection: a rapid advice; 2014.
38.
go back to reference National AIDS/STI Control Program (NASCOP). Guidelines for antiretroviral therapy in Kenya. 4th Edition. Nairobi, Kenya; 2011. National AIDS/STI Control Program (NASCOP). Guidelines for antiretroviral therapy in Kenya. 4th Edition. Nairobi, Kenya; 2011.
39.
go back to reference • Yotebieng M, Brazier E, Addison D, Kimmel AD, Cornell M, Keiser O, et al. Research priorities to inform "treat all" policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the international epidemiology databases to evaluate AIDS (IeDEA). J Int AIDS Soc. 2019;22(1):e25218. https://doi.org/10.1002/jia2.25218 This paper specifically notes that improving linkage to HIV care is a critical research priority for Sub-Saharan Africa in the era of Treat All. CrossRefPubMedPubMedCentral • Yotebieng M, Brazier E, Addison D, Kimmel AD, Cornell M, Keiser O, et al. Research priorities to inform "treat all" policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the international epidemiology databases to evaluate AIDS (IeDEA). J Int AIDS Soc. 2019;22(1):e25218. https://​doi.​org/​10.​1002/​jia2.​25218 This paper specifically notes that improving linkage to HIV care is a critical research priority for Sub-Saharan Africa in the era of Treat All. CrossRefPubMedPubMedCentral
40.
go back to reference World Health Organization. WHO HIV policy adoption and implementation status in countries. WHO; 2018. World Health Organization. WHO HIV policy adoption and implementation status in countries. WHO; 2018.
42.
go back to reference Gentilini U. Revisiting the ‘cash versus food’ debate: new evidence for an old puzzle. World Bank Res Obs. 2016;31:135–67. Gentilini U. Revisiting the ‘cash versus food’ debate: new evidence for an old puzzle. World Bank Res Obs. 2016;31:135–67.
43.
go back to reference Thurow L. Cash versus in-kind transfers. Am Econ Rev. 1974;64(2):190–5. Thurow L. Cash versus in-kind transfers. Am Econ Rev. 1974;64(2):190–5.
Metadata
Title
Interventions to Improve Linkage to HIV Care in the Era of “Treat All” in Sub-Saharan Africa: a Systematic Review
Authors
Nicole Kelly
Werner Maokola
Omobola Mudasiru
Sandra I. McCoy
Publication date
01-08-2019
Publisher
Springer US
Published in
Current HIV/AIDS Reports / Issue 4/2019
Print ISSN: 1548-3568
Electronic ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-019-00451-8

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