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European Journal of Medical Research
Published in: European Journal of Medical Research 1/2023

Open Access 01-12-2023 | Cancer Therapy | Review

Mesenchymal stem cells-derived exosomes: novel carriers for nanoparticle to combat cancer

Authors: Reza Abbasi, Raziye Momen Mesgin, Fereshteh Nazari-Khanamiri, Nima Abdyazdani, Zeynab Imani, Shabnam Pirnezhad Talatapeh, Aidin Nourmohammadi, Vahid Nejati, Jafar Rezaie

Published in: European Journal of Medical Research | Issue 1/2023

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Abstract

Background

The advancement in novel cancer therapeutics brought a platform combining the properties of exosomes with nanoparticles to precision medicine. The novel therapeutic approach aim is cancer-targeted therapy. Exosomes from mesenchymal stem cells (MSCs-Exo) exhibit unique properties in cancer therapies, which makes them an ideal tool for delivering therapeutic agents into tumor cells.

The main body of the abstract

The key role of natural MSCs-Exo is controversial in cancer therapy; however, they can be engineered at their surface or cargo to serve as a smart drug delivery system for cancer-targeted therapy. In the last few years, researchers harnessed nanotechnology to enforce MSCs-Exo for cancer management including, tumor cell tracking, imaging, and tumor cell killing. Different nanoparticles such as gold nanoparticles have particularly been incorporated into MSCs-Exo, which showed an efficient accumulation at the site of tumor with improved anticancer impact. These findings indicate that a hybrid of exosomes–nanoparticles may serve as combination therapy for the effective removal of cancers.

Short conclusion

Although exhibiting impressive potential, the use of nanoparticle-loaded MSCs-Exo as a drug-delivery tool has been troubled by some challenges, therefore, translation to clinic prerequisites further scrutiny. In this review, we focus on nanoparticle-loaded MSCs-Exo as a new cancer therapy and discuss engineered MSC-Exo for target therapy.
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Metadata
Title
Mesenchymal stem cells-derived exosomes: novel carriers for nanoparticle to combat cancer
Authors
Reza Abbasi
Raziye Momen Mesgin
Fereshteh Nazari-Khanamiri
Nima Abdyazdani
Zeynab Imani
Shabnam Pirnezhad Talatapeh
Aidin Nourmohammadi
Vahid Nejati
Jafar Rezaie
Publication date
01-12-2023
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-023-01556-y

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