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BMC Urology
Published in: BMC Urology 1/2023

Open Access 25-07-2023 | Cancer in Pregnancy | Case report

Surgical resection of retinoblastoma-associated bladder leiomyosarcoma during pregnancy: a case report

Authors: Hayato Hoshina, Satoru Taguchi, Hikaru Suyama, Kenjiro Kishitani, Yoshiyuki Akiyama, Yuta Yamada, Yusuke Sato, Daisuke Yamada, Naoya Akiba, Keiichi Kumasawa, Mayuyo Mori-Uchino, Yutaka Osuga, Haruki Kume

Published in: BMC Urology | Issue 1/2023

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Abstract

Background

Management of a bladder tumor during pregnancy is an uncommon clinical situation. Leiomyosarcoma of the urinary bladder is a rare histological type of bladder tumor and a rare secondary cancer in survivors of retinoblastoma (RB). However, there has been no report of RB-associated bladder leiomyosarcoma during pregnancy.

Case presentation

A 37-year-old pregnant woman with a medical history of RB in infancy presented with gross hematuria at the 17th week of gestation. Cystoscopy revealed a 40-mm papillary tumor on the left lateral wall of the urinary bladder. At the 25th week of gestation, she underwent transurethral resection of the bladder tumor, and the pathological diagnosis was bladder leiomyosarcoma with loss of RB1 expression. At the 31st week of gestation, she gave birth by caesarean section. One month after the delivery (to allow for involution of the uterus), she underwent partial cystectomy, and the specimen contained no residual leiomyosarcoma tissue.

Conclusions

We have reported a case of RB-associated bladder leiomyosarcoma that was successfully treated during and after pregnancy.
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Metadata
Title
Surgical resection of retinoblastoma-associated bladder leiomyosarcoma during pregnancy: a case report
Authors
Hayato Hoshina
Satoru Taguchi
Hikaru Suyama
Kenjiro Kishitani
Yoshiyuki Akiyama
Yuta Yamada
Yusuke Sato
Daisuke Yamada
Naoya Akiba
Keiichi Kumasawa
Mayuyo Mori-Uchino
Yutaka Osuga
Haruki Kume
Publication date
25-07-2023
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2023
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/s12894-023-01298-3

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